ANNA TROPEA

@policlinicogemelli.it

Medical Doctor. Department of Obstetrics and Gynecology
Fondazione Policlinico Universitario A. Gemelli IRCCS-Roma

ANNA TROPEA


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https://researchid.co/anna.tropea

RESEARCH INTERESTS

Obstetrics & Gynecology
46

Scopus Publications

Scopus Publications

  • Functional hypothalamic amenorrhea and anti-Müllerian hormone: insights for fertility assessment
    Giovanna Notaristefano, Anna Tropea, Anastasiya Samasiuk, Monia Ranalli, Martina Asia Policriti, Alice Diterlizzi, Tullio Ghi, Antonio Lanzone, Rosanna Apa
    Journal of Endocrinological Investigation, 2026
    Background Anti-Müllerian hormone (AMH) is widely used as a marker of ovarian reserve. However, its reliability in functional hypothalamic amenorrhea (FHA) remains debated. FHA is characterized by reduced gonadotropin secretion and impaired folliculogenesis, which may influence AMH expression and lead to an underestimation of reproductive potential. Methods We conducted a case–control study including women diagnosed with FHA and age-matched healthy controls. FHA patients were stratified according to the presence or absence of polycystic ovarian morphology (PCOM). Serum gonadotropins, estradiol, androgens, and AMH were measured and compared between groups. Correlation analyses were performed to explore associations among hormonal parameters. Results Overall, AMH concentrations in FHA patients were comparable to those of controls. However, stratification revealed that FHA without PCOM was associated with significantly reduced AMH, whereas FHA with PCOM displayed increased values. FHA patients also showed reduced gonadotropins, estradiol, and androgens compared with controls. In the non-PCOM FHA subgroup, AMH correlated positively with androgens and negatively with estradiol. These findings suggest that suppression of gonadotropins and consequent androgen deficiency may contribute to reduced AMH levels in FHA. Conclusions This pilot study indicates that low AMH in FHA may reflect hypothalamic suppression of gonadotropins rather than true ovarian reserve potentially leading to misinterpretation in fertility counseling. These observations should be interpreted with caution given the small sample size, but they support the hypothesis that AMH levels might recover with restoration of hypothalamic–pituitary activity and menstrual cycles. Larger, longitudinal studies are warranted to confirm the reversibility of AMH and clarify its prognostic value in FHA. Graphical abstract Proposed mechanism linking hypothalamic suppression to reduced AMH levels in functional hypothalamic amenorrhea (FHA). Reduced GnRH pulsatility leads to decreased LH secretion and consequent reduction in ovarian androgen production. The resulting hypoandrogenic environment impairs granulosa cell function and attenuates AMH production, reflecting a functional and potentially reversible suppression rather than an irreversible depletion of ovarian reserve.
  • Different Glucose Variability in Women With Polycystic Ovary Syndrome With and Without Insulin Resistance: A Pilot Study
    Alessandro Rizzi, Teresa Polimeno, Maria Laura Leo, Ambra Moriconi, Martina Policriti, Linda Tartaglione, Annamaria Merola, Anna Tropea, Rosanna Apa, Dario Pitocco
    Endocrine Practice, 2025
    OBJECTIVE: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder that affects 10% to 13% of women of reproductive age, and it is often associated with insulin resistance (IR). There is a lack of evidence about glucose profiles evaluated throughout continuous glucose monitoring (CGM) in women with PCOS, especially according to the presence of IR. METHODS: Women with PCOS ≥18 years old underwent CGM (Freestyle Libre 2, Abbott) for 14 days. IR was defined by homeostatic model assessment for IR >2 or quantitative insulin sensitivity check index <0.357. CGM metrics were compared between the 2 groups. Associations between hormonal assays and CGM metrics were also evaluated. RESULTS: ), time in range (70-180 mg/dL) and time in tight range (70-140 mg/dL) were comparable between women with and without IR (P > .05). Regardless of the score used to evaluate IR, women with IR presented a lower coefficient of variation (CV) compared with those without IR (using homeostatic model assessment for IR, CV non-IR 17.1 [12.0-19.8] versus IR 13.5 [11.2-15.5], P = .04; using quantitative insulin sensitivity check index non-IR 17.3 [11.2-19.9] versus IR 13.8 [10.9-15.7], P = .04). Follicle-stimulating hormone was also correlated with mean sensor glucose, time spent above 140 mg/dL, and glucose management indicator. CONCLUSION: Women with PCOS presented overall good glucose control. No differences in time in range and time in tight range were detected, but women with IR presented a lower CV.
  • Use of progestin-only drospirenone-based pills in hyperandrogenic women with polycystic ovary syndrome
    Alice Diterlizzi, Anna Tropea, Eleonora De Luca, Cristina Guerriero, Annamaria Merola, Giovanna Notaristefano, Ambra Moricone, Martina Policriti, Monia Ranalli, Anastasyia Samasiuk, Tullio Ghi, Antonio Lanzone, Rosanna Apa
    Archives of Gynecology and Obstetrics, 2025
    PURPOSE: Polycystic ovarian syndrome (PCOS) is a common endocrine-metabolic disorder affecting about 10% of reproductive-age women. Characterized by hyperandrogenism and ovulatory dysfunction, PCOS often involves metabolic features due to insulin resistance. Traditional treatment with combined oral contraceptive pills (COCP) effectively manages hyperandrogenism and menstrual irregularities. However, drospirenone-only pills (DRSP) may offer a viable alternative for patients who cannot take estrogen-based contraceptives due to cardiovascular risks or personal preference, owing to drospirenone's antiandrogenic properties and improved bleeding profile. This study aimed to evaluate the effects of DRSP-only pills on hyperandrogenism in PCOS patients. Secondary objectives included assessing changes in metabolic and hormonal features and bleeding profiles during therapy. MATERIALS AND METHODS: This monocentric observational retrospective study included 25 hyperandrogenic PCOS patients, aged 16 to 35, treated at Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome. Patients were prescribed DRSP-only therapy for 6 months. Clinical evaluations included ultrasonography, hormonal assays, and dermatological assessments using the Comprehensive Acne Severity Scale (CASS) and the modified Ferriman-Gallwey (mFG) score. Statistical analysis was performed using the two-tailed Wilcoxon test, with significance set at p < 0.05. RESULTS: After 6 months of DRSP-only therapy, there was a significant reduction in CASS scores (2.4-1.8, p = 0.02) and mFG scores (12.31-6.31, p = 0.0053). In addition, significant reductions in 17-OH-progesterone (0.6-0.3 ng/ml, p = 0.03) and basal LH levels (5.8-3.55 UI/ml, p = 0.01) were observed. A trend toward a reduction in CRP levels (1.6-0.5 mg/l, p = 0.06) was noted. Any worsening in metabolic parameters was noted. Bleeding patterns were consistent with literature, with initial spotting decreasing over time. CONCLUSIONS: This study showed that a 6-month drospirenone (DRSP)-only therapy significantly reduced hyperandrogenism symptoms, such as acne and hirsutism, in PCOS patients. It also lowered 17-OH-progesterone levels and showed a trend of reduced CRP values. Bleeding patterns were consistent with those in existing literature. We recommend DRSP-only therapy as a suitable option for PCOS patients with hyperandrogenism who cannot use combined oral contraceptives (COCs), as well as to minimize the metabolic risks of estrogen.
  • Chorio-retinal vessel density in women affected by functional hypothalamic amenorrhea: a monocentric observational cross-sectional study to evaluate the impact of hypoestrogenism on chorio-retinal vascularization
    Alice Diterlizzi, Anna Tropea, Emanuela Angelini, Valentina Cestrone, Romina Fasciani, Annamaria Merola, Giovanna Notaristefano, Martina Asia Policriti, Teresa Polimeno, Monia Ranalli, Maria Cristina Savastano, Ghazal Tannous, Valeria Versace, Stanislao Rizzo, Giovanni Scambia, Antonio Lanzone, Rosanna Apa
    Archives of Gynecology and Obstetrics, 2024
    Purpose Functional hypothalamic amenorrhea (FHA) is characterized by an estrogen deficiency which in turn can cause vascular dysfunction. The aim of this study is to evaluate any changes in the chorio-retinal circulation in patients affected by FHA. 24 patients with FHA and 24 age-matched controls underwent a gynecological evaluation and an OCT angiography (OCTA) to study chorio-retinal vascularization. Results OCTA in FHA patients showed an increase in vessel density in the choriocapillaris (CC) layer (both in the fovea area, at 5% p value = 0.037 and in the whole area, at 5% p value = 0.028) and an increase in vascular density in the deep fovea (DVP) (at 10% p value = 0.096) in the whole district compared to controls. Simple linear regressions show a significant negative association between CC vessel density and insulin (p = 0.0002) and glucose values (p = 0.0335) for the fovea district and a negative association between DVP vessel density and endometrial thickness (at 10%, p value: 0.095) in the whole district. Conclusion Our study shows that CC vessel density is increased in women affected by FHA. This could represent a compensation effort to supply the vascular dysfunction caused by estrogen deficiency. We also found an increasing trend in vascular density in DVP associated with the decrease of endometrial thickness, an indirect sign of estrogenization. Considering that these changes occur in absence of visual defects, they could be used as a biomarker to estimate hypoestrogenism-induced microcirculation changes before clinical appearance.
  • Effects of Ghrelin on Plasminogen Activator Activity in Human Umbilical Vein Endothelial Cells
    Elisabetta Fiacco, Giovanna Notaristefano, Anna Tropea, Rosanna Apa, Rita Canipari
    Endocrines, 2024
    Ghrelin and its growth hormone secretagogue receptor (GHSR) have been found in the placenta, both in endothelial and trophoblast cells. Ghrelin has been shown to decrease blood pressure in several systems and improve endothelial function by stimulating VEGF production. Because locally increased Ghrelin was detected in the preeclamptic fetoplacental unit, we hypothesized its involvement in the fibrinolysis and vascular tone typically observed in preeclamptic patients. This study aimed to evaluate the synthesis of plasminogen activators (PAs), PA inhibitor-1 (PAI-1), and urokinase-type PA (uPA) receptor (uPAR) in human umbilical vein endothelial cells (HUVECs) since the components of the PA/plasmin system are vital players in the extracellular matrix remodeling process necessary for angiogenesis. HUVECs were treated for 24 h with increasing concentrations of Ghrelin (10−11–10−7 M) or IL-1β (0.1 ng/mL). PAs, PAI-1, and uPAR mRNAs were determined by real-time PCR and PA activity was determined by casein underlay. We demonstrated an increase in uPA, tissue-type PA (tPA), and uPAR mRNA; a reduction in PAI-1 mRNA in HUVECs treated with Ghrelin; and an increase in total uPA activity. In conclusion, our results suggest a potential compensatory physiological mechanism for Ghrelin in response to the maternal endothelial dysfunction observed in the preeclamptic fetoplacental unit.
  • Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration
    Giovanna Notaristefano, Francesca Romana Ponziani, Monia Ranalli, Alice Diterlizzi, Martina Asia Policriti, Leonardo Stella, Fabio Del Zompo, Francesca Fianchi, Anna Picca, Valentina Petito, Federica Del Chierico, Matteo Scanu, Francesca Toto, Lorenza Putignani, Emanuele Marzetti, Daniele Ferrarese, Maria Cristina Mele, Annamaria Merola, Anna Tropea, Antonio Gasbarrini, Giovanni Scambia, Antonio Lanzone, Rosanna Apa
    American Journal of Physiology Endocrinology and Metabolism, 2024
    Our study marks the first comprehensive analysis of gut microbiota composition in FHA and the impact of HRT on it, along with biochemical, anthropometric, and psychometric aspects. Our results indicate distinct gut microbiota composition in patients with FHA compared with healthy individuals. Importantly, HRT prompts a transition toward a more beneficial gut microbiota profile and reduced inflammation. This study validates the concept of FHA as a multifaceted disorder interlinked with dysbiosis, particularly involving the gut-brain axis.
  • Insulin-sensitizing effect and antioxidant action of alpha lipoic acid in oligomenorrheic women with polycystic ovary syndrome
    Elisa SCARINCI, Giovanna NOTARISTEFANO, Anna TROPEA, Simone M. FABOZZI, Ornella ALESIANI, Elisabetta MEUCCI, Andrea SILVESTRINI, Marco CINTONI, Alice DITERLIZZI, Antonio LANZONE, Rosanna APA
    Minerva Obstetrics and Gynecology, 2023
    BACKGROUND Polycystic ovary syndrome (PCOS) is a low-grade inflammatory disease characterized by anovulation and hyperandrogenism, associated with insulin-resistance. The aim of our study was to investigate the effects of a treatment with alpha-lipoic acid on clinical, endocrine and metabolic features of women affected by PCOS. METHODS In this pilot cohort study, 60 women (30 hyperinsulinemic and 30 normoinsulinemic patients; age 15-34 years) were enrolled and clinical, hormonal and metabolic parameters were evaluated before and after a six-months treatment with alpha-lipoic acid 800 mg/daily. Investigations were performed during the early follicular phase of the menstrual cycles (spontaneous or progestin-induced cycles): after fasting overnight for 10-12 h, blood samples were collected for hormonal and metabolic assays and oral glucose tolerance test and pelvic ultrasound were performed. Total Antioxidant Capacity was expressed as LAG time. RESULTS The treatment was able to increase the number of menstrual cycles during the 6 months considered in all patients and to reduce BMI in the normoinsulinemic population. In hyperinsulinemic patients we observed a statistically significant reduction in AUC-I as well as an increase of total antioxidant capacity. CONCLUSIONS The relevant results in restoring menstrual cyclicity in both groups, in addition to the antioxidant effect, confirm that hyperinsulinemia influences only the metabolic response to the treatment, without predict the ovarian function. Even if alpha-lipoic acid mechanisms of action is not clear and further studies are needed to confirm these results, it could be considered a valid therapeutic alternative to traditional drugs, without side effects as reported.
  • Circulating irisin levels in functional hypothalamic amenorrhea: a new bone damage index? A pilot study
    Giovanna Notaristefano, Annamaria Merola, Elisa Scarinci, Nicolò Ubaldi, Monia Ranalli, Anna Tropea, Alice Diterlizzi, Simone Michele Fabozzi, Ornella Alesiani, Andrea Silvestrini, Alvaro Mordente, Esmeralda Capristo, Antonio Lanzone, Rosanna Apa
    Endocrine, 2022
    Purpose Patients with functional hypothalamic amenorrhea (FHA) could commonly have bone damage, often preceded by metabolic alterations due to a relative energy deficit state. To date, there are no markers capable of predicting osteopenia before it is manifested on DXA. Irisin is a myokine that promotes the differentiation of osteoblastic cells and appears to be inversely correlated with the incidence of bone fragility and fractures in postmenopausal women. The aim of this study was to measure irisin levels in FHA patients and to correlate it with bone density parameters. Methods Thirty-two patients with FHA and 19 matched controls underwent the same clinical and laboratory evaluation. Results Irisin and body mass index (BMI) were significantly lower in the case group than in healthy controls (2.03 ± 0.12 vs. 2.42 ± 0.09 p &lt; 0.05 and 19.43 ± 2.26 vs. 22.72 ± 0.67 p &lt; 0.05, respectively). Additionally, total body mass density (BMD g/cm2) was significantly lower in the case group than in the healthy controls (1.09 ± 0.08 vs. 1.14 ± 0.05, p &lt; 0.05), without signs of osteopenia. Conclusions The FHA group showed lower irisin levels associated with significantly reduced BMD parameters that did not reach the severity of osteopenia. Therefore, we could speculate that irisin could predict DXA results in assessing modifications of body composition parameters. Future research is warranted to study these parameters in a larger population to confirm our results, so that irisin could be used as a predictor and screening method for bone deprivation. Furthermore, irisin is strictly related to energy metabolism and could be an indirect marker of nutritional status in FHA patients, identifying earlier states of energy deficit.
  • Management of vertigo in pregnancy
    A. Salvati, R. Apa, A. Loperfido, E. Scarano, G. Paludetti, A. Tropea, P.M. Picciotti
    Italian Journal of Gynaecology and Obstetrics, 2020
    Background. Pregnancy is a specific female physiological period characterized by significant changes, included otological and neurotological manifestations. Vestibular disorders like vertigo and dizziness, are common complaints from pregnant women to primary care. Objectives. The aim of this paper is to describe clinical pictures, evaluation methods and therapeutic options of acute vertigo in pregnancy with the related pathogenetic hypotheses. Method. We describe 11 cases of vertigo in pregnancy. All patients underwent audio-vestibular evaluation, consisting of pure-tone audiometry, impedance and clinical testing of the vestibular function, the "bed side examination". Results. Audiological evaluation showed normal puretone audiometry and impedance in 10 patients. Only in one case a sudden right total deafness was highlighted with vestibular areflexia, showing a secondary positional vertigo. Seven patients presented a benign paroxysmal positional vertigo (BPPV) effectively treated by liberatory maneuvers. Three patients had a diagnosis of vestibular neuritis and they were treated with corticosteroids therapy with a complete resolution of dizziness and vertigo in one month. Conclusions. Our results point out the importance of multidisciplinarity between otolaryngologist, neurologist and gynecologist. From a pathogenic point of view, the vascular etiology, strictly related to the gravidic hormonal variations, is often hypothesized.
  • “Hormone of darkness” and human reproductive process: direct regulatory role of melatonin in human corpus luteum
    E. Scarinci, A. Tropea, G. Notaristefano, V. Arena, O. Alesiani, S. M. Fabozzi, A. Lanzone, R. Apa
    Journal of Endocrinological Investigation, 2019
    PurposeTo investigate the possible role of melatonin on human luteal cell function.MethodsCorpora lutea were obtained from normally menstruating women (25–38 years old) in the midluteal phase (days 5–6 from ovulation) at the time of surgery for non-endocrine gynecologic diseases. The protocol was approved by the institutional review board of Università Cattolica del Sacro Cuore in Rome and all patients provided written informed consent. The corpora lutea were dated on the basis of the presumptive day of ovulation (day 0) , determined by urinary luteinizing hormone (LH) peak, ultrasound detection of corpus luteum or disappearance of the dominant follicle, and a rise in the plasma P concentration. ELISA or EIA kit and immunohistochemistry were performed.ResultsMelatonin was able to increase progesterone release and to influence the balance between luteotrophic and luteolityc factors. In addition, melatonin expression and MT2 receptor were detected, confirming the direct action of this indoleamine on CL.ConclusionsMelatonin may play an intriguing role in direct regulation of CL function and in establishing and maintaining of initial pregnancy. In conclusion, melatonin could become a relevant medication for improving ovarian and luteal function and in the early stages of pregnancy, opening new opportunities for the management of several ovarian-luteal and pregnancy diseases.
  • Increased fibulin-1 plasma levels in polycystic ovary syndrome (PCOS) patients: possible contribution to the link between PCOS and cardiovascular risk
    E. Scarinci, A. Tropea, G. Russo, G. Notaristefano, C. Messana, O. Alesiani, S. M. Fabozzi, A. Lanzone, R. Apa
    Journal of Endocrinological Investigation, 2019
  • Melatonin Treatment May Be Able to Restore Menstrual Cyclicity in Women With PCOS: A Pilot Study
    Valeria Tagliaferri, Daniela Romualdi, Elisa Scarinci, Simona De Cicco, Christian Di Florio, Valentina Immediata, Anna Tropea, Carla Mariaflavia Santarsiero, Antonio Lanzone, Rosanna Apa
    Reproductive Sciences, 2018
  • Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action
    Simona De Cicco, Valentina Immediata, Daniela Romualdi, Caterina Policola, Anna Tropea, Christian Di Florio, Valeria Tagliaferri, Elisa Scarinci, Silvia Della Casa, Antonio Lanzone, Rosanna Apa
    Gynecological Endocrinology, 2017
  • Anti-Müllerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination
    Francesca Moro, Anna Tropea, Elisa Scarinci, Emanuele Leoncini, Stefania Boccia, Alex Federico, Ornella Alesiani, Antonio Lanzone, Rosanna Apa
    International Journal of Gynecology and Obstetrics, 2016
  • Psoriasis and polycystic ovary syndrome: A new link in different phenotypes
    Francesca Moro, Anna Tropea, Elisa Scarinci, Alex Federico, Clara De Simone, Giacomo Caldarola, Emanuele Leoncini, Stefania Boccia, Antonio Lanzone, Rosanna Apa
    European Journal of Obstetrics and Gynecology and Reproductive Biology, 2015
  • Hysterosalpingo-contrast-sonography (HyCoSy) in the assessment of tubal patency in endometriosis patients
    Francesca Moro, Anna Tropea, Luigi Selvaggi, Elisa Scarinci, Antonio Lanzone, Rosanna Apa
    European Journal of Obstetrics and Gynecology and Reproductive Biology, 2015
  • Highly purified hMG versus recombinant FSH plus recombinant LH in intrauterine insemination cycles in women ≥35 years: A RCT
    F. Moro, E. Scarinci, C. Palla, F. Romani, A. Familiari, A. Tropea, E. Leoncini, A. Lanzone, R. Apa
    Human Reproduction, 2015
  • A Possible Role of Polycystic Ovary Syndrome for Pregnancy Complications in Women with Psoriasis
    Clara De Simone, Giacomo Caldarola, Marialuisa Corbeddu, Francesca Moro, Anna Tropea, Gaia Moretta, Rosanna Apa
    Drug Development Research, 2014
  • Endocrine disruptors and human reproductive failure: The in vitro effect of phthalates on human luteal cells
    Federica Romani, Anna Tropea, Elisa Scarinci, Alex Federico, Cinzia Dello Russo, Lucia Lisi, Stefania Catino, Antonio Lanzone, Rosanna Apa
    Fertility and Sterility, 2014
  • Assessment of insulin resistance in lean women with polycystic ovary syndrome
    Andrea Morciano, Federica Romani, Francesca Sagnella, Elisa Scarinci, Carola Palla, Francesca Moro, Anna Tropea, Caterina Policola, Silvia Della Casa, Maurizio Guido, Antonio Lanzone, Rosanna Apa
    Fertility and Sterility, 2014
  • Effects of drospirenone-ethinylestradiol and/or metformin on CD4 +CD28null T lymphocytes frequency in women with hyperinsulinemia having polycystic ovary syndrome: A randomized clinical trial
    Francesca Moro, Andrea Morciano, Anna Tropea, Francesca Sagnella, Carola Palla, Elisa Scarinci, Andrea Ciardulli, Daniela Martinez, Alessandra Familiari, Giovanna Liuzzo, Alessandra Tritarelli, Nicola Cosentino, Giampaolo Niccoli, Filippo Crea, Antonio Lanzone, Rosanna Apa
    Reproductive Sciences, 2013
  • Psoriatic patients have an increased risk of polycystic ovary syndrome: Results of a cross-sectional analysis
    Francesca Moro, Clara De Simone, Andrea Morciano, Anna Tropea, Francesca Sagnella, Carola Palla, Elisa Scarinci, Angela Teti, Giacomo Caldarola, Magda D'Agostino, Salvatore Mancuso, Antonio Lanzone, Rosanna Apa
    Fertility and Sterility, 2013
  • Endocrine disruptors and human corpus luteum: In vitro effects of phenols on luteal cells function
    Federica Romani, Anna Tropea, Elisa Scarinci, Cinzia Dello Russo, Lucia Lisi, Stefania Catino, Antonio Lanzone, Rosanna Apa
    Journal of Environmental Science and Health Part C Environmental Carcinogenesis and Ecotoxicology Reviews, 2013
  • CD4+CD28null T lymphocyte frequency, a new marker of cardiovascular risk: Relationship with polycystic ovary syndrome phenotypes
    Francesca Moro, Andrea Morciano, Anna Tropea, Francesca Sagnella, Carola Palla, Elisa Scarinci, Nicola Cosentino, Giampaolo Niccoli, Giovanna Liuzzo, Filippo Crea, Antonio Lanzone, Rosanna Apa
    Fertility and Sterility, 2012
  • In vitro effect of unacylated ghrelin and obestatin on human luteal cell function
    Federica Romani, Antonio Lanzone, Anna Tropea, Alessandra Familiari, Elisa Scarinci, Michela Sali, Giovanni Delogu, Stefania Catino, Rosanna Apa
    Fertility and Sterility, 2012
  • Could antispasmodic drug reduce pain during hysterosalpingo-contrast sonography (HyCoSy) in infertile patients? A randomized double-blind clinical trial
    F. Moro, L. Selvaggi, F. Sagnella, A. Morciano, D. Martinez, M. F. Gangale, A. Ciardulli, C. Palla, M. L. Uras, E. De Feo, S. Boccia, A. Tropea, A. Lanzone, R. Apa
    Ultrasound in Obstetrics and Gynecology, 2012
  • Long-term metformin treatment is able to reduce the prevalence of metabolic syndrome and its hepatic involvement in young hyperinsulinaemic overweight patients with polycystic ovarian syndrome
    Maria F. Gangale, Luca Miele, Antonio Lanzone, Francesca Sagnella, Daniela Martinez, Anna Tropea, Francesca Moro, Andrea Morciano, Andrea Ciardulli, Carola Palla, Maurizio Pompili, Consuelo Cefalo, Antonio Grieco, Rosanna Apa
    Clinical Endocrinology, 2011
  • CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome
    Giampaolo Niccoli, Rosanna Apa, Antonio Lanzone, Giovanna Liuzzo, Cristina Spaziani, Francesca Sagnella, Nicola Cosentino, Francesca Moro, Daniela Martinez, Andrea Morciano, Marco Bacà, Vincenzo Pazzano, Maria Francesca Gangale, Anna Tropea, Filippo Crea
    Fertility and Sterility, 2011
  • Nicotine and cotinine affect the release of vasoactive factors by trophoblast cells and human umbilical vein endothelial cells
    F. Romani, A. Lanzone, A. Tropea, F. Tiberi, S. Catino, R. Apa
    Placenta, 2011
  • A prospective randomized noninferiority study comparing recombinant FSH and highly purified menotropin in intrauterine insemination cycles in couples with unexplained infertility and/or mild-moderate male factor
    Francesca Sagnella, Francesca Moro, Antonio Lanzone, Anna Tropea, Daniela Martinez, Antonio Capalbo, Maria Francesca Gangale, Valentina Spadoni, Andrea Morciano, Rosanna Apa
    Fertility and Sterility, 2011
  • Prokineticin 1, homeobox A10, and progesterone receptor messenger ribonucleic acid expression in primary cultures of endometrial stromal cells isolated from endometrium of healthy women and from eutopic endometrium of women with endometriosis
    Federica Tiberi, Anna Tropea, Federica Romani, Rosanna Apa, Riccardo Marana, Antonio Lanzone
    Fertility and Sterility, 2010
  • Estrogens and androgens affect human luteal cell function
    Anna Tropea, Antonio Lanzone, Federica Tiberi, Federica Romani, Stefania Catino, Rosanna Apa
    Fertility and Sterility, 2010
  • Prokineticin 1 mRNA expression in the endometrium of healthy women and in the eutopic endometrium of women with endometriosis
    Federica Tiberi, Anna Tropea, Rosanna Apa, Federica Romani, Antonio Lanzone, Riccardo Marana
    Fertility and Sterility, 2010
  • Erratum: Paracrine regulation of endometriotic tissue (Gynecological Endocrinology (2007) 23:10 (574-580))
    Gynecological Endocrinology, 2010
  • Endometriosis and human infertility: A new investigation into the role of eutopic endometrium
    F. Minici, F. Tiberi, A. Tropea, M. Orlando, M. F. Gangale, F. Romani, S. Campo, A. Bompiani, A. Lanzone, R. Apa
    Human Reproduction, 2008
  • Ghrelin in vitro modulates vasoactive factors in human umbilical vein endothelial cells
    Francesca Minici, Fiorella Miceli, Federica Tiberi, Anna Tropea, Mariateresa Orlando, Maria Francesca Gangale, Federica Romani, Stefania Catino, Antonio Lanzone, Rosanna Apa
    Fertility and Sterility, 2007
  • Paracrine regulation of endometriotic tissue
    Francesca Minici, Federica Tiberi, Anna Tropea, Fiorella Miceli, Mariateresa Orlando, Maria Francesca Gangale, Federica Romani, Stefania Catino, Sebastiano Campo, Antonio Lanzone, Rosanna Apa
    Gynecological Endocrinology, 2007
  • Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells
    Anna Tropea, Federica Tiberi, Francesca Minici, Mariateresa Orlando, Maria Francesca Gangale, Federica Romani, Fiorella Miceli, Stefania Catino, Salvatore Mancuso, Maurizio Sanguinetti, Antonio Lanzone, Rosanna Apa
    Journal of Clinical Endocrinology and Metabolism, 2007
  • Regulation of vascular endothelial growth factor synthesis and release by human luteal cells in vitro
    Anna Tropea, Fiorella Miceli, Francesca Minici, Federica Tiberi, Mariateresa Orlando, Maria Francesca Gangale, Federica Romani, Stefania Catino, Salvatore Mancuso, Pierluigi Navarra, Antonio Lanzone, Rosanna Apa
    Journal of Clinical Endocrinology and Metabolism, 2006
  • Biology of endometriotic cells
    Giornale Italiano Di Ostetricia E Ginecologia, 2005
  • Effects of nicotine on human luteal cells in vitro: A possible role on reproductive outcome for smoking women
    Fiorella Miceli, Francesca Minici, Anna Tropea, Stefania Catino, Mariateresa Orlando, Giuseppina Lamanna, Francesca Sagnella, Federica Tiberi, Adriano Bompiani, Salvatore Mancuso, Antonio Lanzone, Rosanna Apa
    Biology of Reproduction, 2005
  • Effects of insulin-like growth factor I and II on prostaglandin synthesis and plasminogen activator activity in human umbilical vein endothelial cells
    Fiorella Miceli, Anna Tropea, Francesca Minici, Mariateresa Orlando, Giuseppina Lamanna, Maria Francesca Gangale, Barbara Panetta, Federica Tiberi, Sergio Vaccari, Rita Canipari, Antonio Lanzone, Rosanna Apa
    Journal of Clinical Endocrinology and Metabolism, 2005
  • Endometrial evaluation in superovulation programs: Relationship with successful outcome
    ANNA TROPEA, FIORELLA MICELI, FRANCESCA MINICI, MARIATERESA ORLANDO, GIUSEPPINA LAMANNA, MARIAFRANCESCA GANGALE, STEFANIA CATINO, ANTONIO LANZONE, ROSANNA APA
    Annals of the New York Academy of Sciences, 2004
  • Endothelin
    Cuadernos De Medicina Reproductiva, 2003
  • The effects of nitric oxide on prostanoid production and release by human umbilical vein endothelial cells
    Fiorella Miceli, Giuseppe Tringali, Anna Tropea, Francesca Minici, Maria Teresa Orlando, Antonio Lanzone, Pierluigi Navarra, Rosanna Apa
    Life Sciences, 2003
  • Interleukin-1β stimulates progesterone production by in vitro human luteal cells: Evidence of a mediatory role of prostaglandins
    Fiorella Miceli, Anna Tropea, Francesca Minici, Pierluigi Navarra, Antonio Lanzone, Rosanna Apa
    Journal of Clinical Endocrinology and Metabolism, 2003