Amanda Rabello Crisma

Scopus Publications

Evidence for a Pro-Inflammatory State of Macrophages from Non-Obese Type-2 Diabetic Goto-Kakizaki Rats
Amanda Santos de Almeida Silveira, Amara Cassandra dos Anjos Alves, Gabriela Mandú Gimenes, Patrícia da Silva Quessada, Tiago Bertola Lobato, Beatriz Belmiro Dias, Ana Carolina Gomes Pereira, Patrícia Nancy Iser-Bem, Joice Naiara Bertaglia Pereira, Elaine Hatanaka, Laureane Nunes Masi, Tânia Cristina Pithon-Curi, Vânia Gomes de Moura Mattaraia, Sandro Massao Hirabara, Amanda Rabello Crisma, Renata Gorjão, Rui Curi
International Journal of Molecular Sciences, 2024
Obesity causes insulin resistance (IR) through systemic low-grade inflammation and can lead to type 2 diabetes mellitus (T2DM). However, the mechanisms that cause IR and T2DM in non-obese individuals are unclear. The Goto-Kakizaki (GK) rat develops IR spontaneously and is a model of non-obese T2DM. These rats exhibit hyperglycemia beginning at weaning and exhibit lower body mass than control Wistar rats. Herein, we tested the hypothesis that macrophages of GK rats are permanently in a pro-inflammatory state, which may be associated with a systemic inflammation condition that mimics the pathogenesis of obesity-induced T2DM. Using eighteen-week-old GK and control Wistar rats, we investigated the proportions of M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages isolated from the peritoneal cavity. Additionally, the production of inflammatory cytokines and reactive oxygen species (ROS) in cultured macrophages under basal and stimulated conditions was assessed. It was found that phorbol myristate acetate (PMA) stimulation increased GK rat macrophage ROS production 90-fold compared to basal levels. This response was also three times more pronounced than in control cells (36-fold). The production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), tended to be upregulated in cultured macrophages from GK rats under basal conditions. Macrophages from GK rats produced 1.6 times more granulocyte-macrophage colony-stimulating factor (GM-CSF), 1.5 times more monocyte chemoattractant protein-1 (MCP-1) and 3.3 times more TNF-α than control cells when stimulated with lipopolysaccharide (LPS) (p = 0.0033; p = 0.049; p = 0.002, respectively). Moreover, compared to control cells, GK rats had 60% more M1 (p = 0.0008) and 23% less M2 (p = 0.038) macrophages. This study is the first to report macrophage inflammatory reprogramming towards a pro-inflammatory state in GK rats.
Maternal low-protein diet reduces skeletal muscle protein synthesis and mass via Akt-mTOR pathway in adult rats
Diogo Antonio Alves de Vasconcelos, Renato Tadeu Nachbar, Carlos Hermano Pinheiro, Cátia Lira do Amaral, Amanda Rabello Crisma, Kaio Fernando Vitzel, Phablo Abreu, Maria Isabel Alonso-Vale, Andressa Bolsoni Lopes, Adriano Bento-Santos, Filippe Falcão-Tebas, David Filipe de Santana, Elizabeth do Nascimento, Rui Curi, Tania Cristina Pithon-Curi, Sandro Massao Hirabara, Carol Góis Leandro
Frontiers in Nutrition, 2022
Several studies have demonstrated that a maternal low-protein diet induces long-term metabolic disorders, but the involved mechanisms are unclear. This study investigated the molecular effects of a low-protein diet during pregnancy and lactation on glucose and protein metabolism in soleus muscle isolated from adult male rats. Female rats were fed either a normal protein diet or low-protein diet during gestation and lactation. After weaning, all pups were fed a normal protein diet until the 210th day postpartum. In the 7th month of life, mass, contractile function, protein and glucose metabolism, and the Akt-mTOR pathway were measured in the soleus muscles of male pups. Dry weight and contractile function of soleus muscle in the low-protein diet group rats were found to be lower compared to the control group. Lipid synthesis was evaluated by measuring palmitate incorporation in white adipose tissue. Palmitate incorporation was higher in the white adipose tissue of the low-protein diet group. When incubated soleus muscles were stimulated with insulin, protein synthesis, total amino acid incorporation and free amino acid content, glucose incorporation and uptake, and glycogen synthesis were found to be reduced in low-protein diet group rats. Fasting glycemia was higher in the low-protein diet group. These metabolic changes were associated with a decrease in Akt and GSK-3β signaling responses to insulin and a reduction in RPS6 in the absence of the hormone. There was also notably lower expression of Akt in the isolated soleus muscle of low-protein diet group rats. This study is the first to demonstrate how maternal diet restriction can reduce skeletal muscle protein and mass by downregulating the Akt-mTOR pathway in adulthood.
Propolis authentication of stingless bees by mid-infrared spectroscopy and chemometric analysis
Monica Surek, Alexandre de Fátima Cobre, Mariana Millan Fachi, Thalita Gilda Santos, Roberto Pontarolo, Amanda Rabello Crisma, Karina Bettega Felipe, Wesley Maurício de Souza
Lwt, 2022
Although stingless bees are widespread in tropical and subtropical regions worldwide, their by-products, including propolis, are rarely used. In this study, we aimed to chemically analyze and investigate the potential of mid-infrared (MIR) spectroscopy and chemometric analyses for the authentication of propolis. The content of phenolic compounds and total flavonoids were used as quality parameters according to the guidelines of the Brazilian legislation. Attenuated total reflection-infrared (ATR-IR) spectroscopy was performed, and a chemometric model was developed and validated to discriminate and classify the four samples of propolis. The partial least squares-discriminant analysis (PLS-DA) model was found to be sensitive, specific, and accurate, and can be used for the quality control of these propolis samples for authentication purposes. Plebeia propolis showed the lowest total phenolic and flavonoid content. As suggested by the ATR-IR and confirmed by the determination of total phenolics and flavonoids, only green, tubuna, and mandaçaia propolis met the criteria established by the Brazilian legislation for marketing. In conclusion, the infrared chemometric model developed in this study can be implemented as a tool for the authentication of the studied propolis classes.
The toxicity of Aspidosperma subincanum to MCF7 cells is related to modulation of oxidative status and proinflammatory pathways
Andressa F. Santos, Nádia S.R. Santos Mota, Elberth M. Schiefer, Regiane S. da Cunha, Allan M. Junkert, Andréa E.M. Stinghen, Roberto Pontarolo, Amanda R. Crisma, Almeriane M. Weffort-Santos, Rozangela C. Pedrosa, Wesley M. de Souza, Karina B. Felipe
Journal of Ethnopharmacology, 2021
Changes in PGC-1α-Dependent Mitochondrial Biogenesis Are Associated with Inflexible Hepatic Energy Metabolism in the Offspring Born to Dexamethasone-Treated Mothers
Carolina Vieira Campos, Caio Jordão Teixeira, Tanyara Baliani Payolla, Amanda Rabello Crisma, Gilson Masahiro Murata, Andressa Godoy Amaral, Lucas Carminatti Pantaleão, Frhancielly Shirley Sodré, Mariana Mayumi Onari, Lorena de Souza Almeida, Gizela A. Pereira, Dimitrius Santiago Simões Fróes Guimarães, Leonardo Reis Silveira, Gabriel Forato Anhê, Silvana Bordin
Livers, 2021
In the present study we investigated the participation of hepatic peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) in the metabolic programming of newborn rats exposed in utero to dexamethasone (DEX). On the 21st day of life, fasted offspring born to DEX-treated mothers displayed increased conversion of pyruvate into glucose with simultaneous upregulation of PEPCK (phosphoenolpyruvate carboxykinase) and G6Pase (glucose-6-phosphatase). Increased oxidative phosphorylation, higher ATP/ADP ratio and mitochondrial biogenesis and lower pyruvate levels were also found in the progeny of DEX-treated mothers. On the other hand, the 21-day-old progeny of DEX-treated mothers had increased hepatic triglycerides (TAG) and lower CPT-1 activity when subjected to short-term fasting. At the mechanistic level, rats exposed in utero to DEX exhibited increased hepatic PGC-1α protein content with lower miR-29a-c expression. Increased PGC-1α content was concurrent with increased association to HNF-4α and NRF1 and reduced PPARα expression. The data presented herein reveal that changes in the transcription machinery in neonatal liver of rats born to DEX-treated mothers leads to an inflexible metabolic response to fasting. Such programming is hallmarked by increased oxidative phosphorylation of pyruvate with impaired FFA oxidation and hepatic TAG accumulation.
Correction to: A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome (Microbiome, (2021), 9, 1, (134), 10.1186/s40168-021-01081-2)
Mateus B. Casaro, Andrew M. Thomas, Eduardo Mendes, Claudio Fukumori, Willian R. Ribeiro, Fernando A. Oliveira, Amanda R. Crisma, Gilson M. Murata, Bruna Bizzarro, Anderson Sá-Nunes, Joao C. Setubal, Marcia P. A. Mayer, Flaviano S. Martins, Angélica T. Vieira, Ana T. F. B. Antiorio, Wothan Tavares-de-Lima, Niels O. S. Camara, Rui Curi, Emmanuel Dias-Neto, Caroline M. Ferreira
Microbiome, 2021
© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. The original article can be found online at https://doi.org/10.1186/s40168021-01081-2.
A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome
Mateus B. Casaro, Andrew M. Thomas, Eduardo Mendes, Claudio Fukumori, Willian R. Ribeiro, Fernando A. Oliveira, Amanda R. Crisma, Gilson M. Murata, Bruna Bizzarro, Anderson Sá-Nunes, Joao C. Setubal, Marcia P. A. Mayer, Flaviano S. Martins, Angélica T. Vieira, Ana T. F. B. Antiorio, Wothan Tavares-de-Lima, Niels O. S. Camara, Rui Curi, Emmanuel Dias-Neto, Caroline M. Ferreira
Microbiome, 2021
The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in A/J mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BL/6 mice with A/J embryos to naturally modulate the microbial composition of A/J mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity.
Immunomodulatory and cytotoxic activities of euphol
Thais Latansio de Oliveira, Lorena Bavia, Pâmela Dias Fontana, Luiza Stolz Cruz, Katia Sabrina Paludo, Amanda Rabello Crisma, Iara Jose Messias-Reason, Flávio Luís Beltrame
Life Sciences, 2021
Chemical composition, cytotoxicity, and antibacterial activity of propolis from Africanized honeybees and three different Meliponini species
Monica Surek, Mariana M. Fachi, Alexandre de Fátima Cobre, Favízia F. de Oliveira, Roberto Pontarolo, Amanda R. Crisma, Wesley M. de Souza, Karina B. Felipe
Journal of Ethnopharmacology, 2021
Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils
Thais Latansio de Oliveira, Pâmela Dias Fontana, Lorena Bavia, Luiza Stolz Cruz, Amanda Rabello Crisma, Guilherme Lanzi Sassaki, Leociley Rocha Alencar Menezes, Mei Wang, Flávio Luís Beltrame, Iara Jose Messias-Reason
Journal of Ethnopharmacology, 2021
Macrophage inflammatory state in Type 1 diabetes: Triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L. Corrêa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi
Clinical Science, 2021
Schiefer counter: An alternative method for clonogenic assay evaluation
A.F. Santos, E.M. Schiefer, M.C. Atherino, J.C. Atherino, L.H. Negri, A.M. Weffort-Santos, A.R. Crisma, W.M. de Souza, K.B. Felipe
Journal of Pharmacological and Toxicological Methods, 2020
Tributyrin attenuates metabolic and inflammatory changes associated with obesity through a GPR109A-dependent mechanism
Fabio Takeo Sato, Yu Anne Yap, Amanda Rabello Crisma, Mariana Portovedo, Gilson Masahiro Murata, Sandro Massao Hirabara, Willian Rodrigues Ribeiro, Caroline Marcantonio Ferreira, Maysa Mariana Cruz, Joice Naiara Bertaglia Pereira, Tanyara Baliani Payolla, Suzana Eiko Sato Guima, Andrew Maltez Thomas, João Carlos Setubal, Maria Isabel Cardoso Alonso-Vale, Marinilce Fagundes Santos, Rui Curi, Eliana Marino, Marco A. R. Vinolo
Cells, 2020
Impact of Dietary Fatty Acids on Macrophage Lipid Metabolism, Signaling and Function
Mariana Rodrigues Davanso, Amanda Rabello Crisma, Gilson Murata, Philip Newsholme, Rui Curi
Immunometabolism United States, 2020
Maternal supplementation with a synbiotic has distinct outcomes on offspring gut microbiota formation in A/J and C57BL/6 mice, differentially affecting airway inflammatory cell infiltration and mucus production
Claudio Fukumori, Mateus B. Casaro, Andrew M. Thomas, Eduardo Mendes, Willian R. Ribeiro, Amanda R. Crisma, Gilson M. Murata, Bruna Bizzarro, Emmanuel Dias-Neto, Joao C. Setubal, Maria A. Oliveira, Wothan Tavares-de-Lima, Rui Curi, Silvana Bordin, Patricia Sartorelli, Caroline M. Ferreira
Journal of Functional Foods, 2019
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice
M.M. Antunes, C.B. de Almeida-Souza, G. Godoy, A.R. Crisma, L.N. Masi, R. Curi, R.B. Bazotte
Brazilian Journal of Medical and Biological Research, 2019
Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue
Thamiris Candreva, Carolina M.C. Kühl, Beatriz Burger, Mariah B.P. dos Anjos, Márcio A. Torsoni, Sílvio R. Consonni, Amanda R. Crisma, Helena L. Fisk, Philip C. Calder, Felipe C.P. de Mato, Erica M. Sernaglia, Marco A.R. Vinolo, Hosana G. Rodrigues
Clinical Science, 2019
Greater expression of postprandial inflammatory genes in humans after intervention with saturated when compared to unsaturated fatty acids
Milena Monfort-Pires, Amanda Rabello Crisma, Silvana Bordin, Sandra Roberta G. Ferreira
European Journal of Nutrition, 2018
Brain fatty acid composition and inflammation in mice fed with high-carbohydrate diet or high-fat diet
Lorena Gimenez da Silva-Santi, Marina Masetto Antunes, Marco Aurélio Mori, Camila Biesdorf de Almeida-Souza, Jesuí Vergílio Visentainer, Fabiana Carbonera, Amanda Rabello Crisma, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi, Roberto Barbosa Bazotte
Nutrients, 2018
Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet
Amanda R. Martins, Amanda R. Crisma, Laureane N. Masi, Catia L. Amaral, Gabriel N. Marzuca-Nassr, Lucas H.M. Bomfim, Bruno G. Teodoro, André L. Queiroz, Tamires D.A. Serdan, Rosangela P. Torres, Jorge Mancini-Filho, Alice C. Rodrigues, Tatiana C. Alba-Loureiro, Tania C. Pithon-Curi, Renata Gorjao, Leonardo R. Silveira, Rui Curi, Philip Newsholme, Sandro M. Hirabara
Journal of Nutritional Biochemistry, 2018
Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes
Maysa M. Cruz, Andressa B. Lopes, Amanda R. Crisma, Roberta C. C. de Sá, Wilson M. T. Kuwabara, Rui Curi, Paula B. M. de Andrade, Maria I. C. Alonso-Vale
Lipids in Health and Disease, 2018
Prophylactic Bifidobacterium adolescentis ATTCC 15703 supplementation reduces partially allergic airway disease in Balb/c but not in C57BL/6 mice
M.C. Casaro, A.R. Crisma, A.T. Vieira, G.H.M. Silva, E. Mendes, W.R. Ribeiro, F.S. Martins, C.M. Ferreira
Beneficial Microbes, 2018
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice
Laureane Nunes Masi, Amanda Roque Martins, Amanda Rabello Crisma, Cátia Lira do Amaral, Mariana Rodrigues Davanso, Tamires Duarte Afonso Serdan, Roberta Dourado Cavalcante da Cunha de Sá, Maysa Mariana Cruz, Maria Isabel Cardoso Alonso-Vale, Rosângela Pavan Torres, Jorge Mancini-Filho, Joice Naiara Bertaglia Pereira, Marta Maria da Silva Righetti, Edson Aparecido Liberti, Sandro Massao Hirabara, Rui Curi
Scientific Reports, 2017
Balanced diet-fed fat-1 transgenic mice exhibit lower hindlimb suspension-induced soleus muscle atrophy
Gabriel Nasri Marzuca-Nassr, Gilson Masahiro Murata, Amanda Roque Martins, Kaio Fernando Vitzel, Amanda Rabello Crisma, Rosângela Pavan Torres, Jorge Mancini-Filho, Jing Xuan Kang, Rui Curi
Nutrients, 2017
Prophylactic supplementation of Bifidobacterium longum 51A protects mice from ovariectomy-induced exacerbated allergic airway inflammation and airway hyperresponsiveness
Eduardo Mendes, Beatriz G. Acetturi, Andrew M. Thomas, Flaviano dos S. Martins, Amanda R. Crisma, Gilson Murata, Tárcio T. Braga, Niels O. S. Camâra, Adriana L. dos S. Franco, João C. Setubal, Willian R. Ribeiro, Claudete J. Valduga, Rui Curi, Emmanuel Dias-Neto, Wothan Tavares-de-Lima, Caroline M. Ferreira
Frontiers in Microbiology, 2017
Stereology shows that damaged liver recovers after protein refeeding
Silvio Pires Gomes, Andréa Almeida Pinto da Silva, Amanda Rabello Crisma, Primavera Borelli, Francisco Javier Hernandez-Blazquez, Mariana P. de Melo, Barbara Bacci, Andrzej Loesch, A. Augusto Coppi
Nutrition, 2017
Euphorbia umbellata bark extracts – An in vitro cytotoxic study
Carla C. Kanunfre, Talissa Leffers, Luiza S. Cruz, Lívia E.C. Luz, Amanda R. Crisma, Mei Wang, Bharathi Avula, Ikhlas A. Khan, Flávio L. Beltrame
Revista Brasileira De Farmacognosia, 2017
Inflammatory state of periaortic adipose tissue in mice under obesogenic dietary regimens
Laureane Nunes Masi, Amanda Rabello Crisma, Amanda Roque Martins, Catia Lira do Amaral, Rosângela Pavan Torres, Jorge Mancini Filho, Sandro Massao Hirabara, Rui Curi
Journal of Nutrition and Intermediary Metabolism, 2016
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes
Roberta D. C. da Cunha de Sá, Amanda R. Crisma, Maysa M. Cruz, Amanda R. Martins, Laureane N. Masi, Catia L. do Amaral, R. Curi, Maria I. C. Alonso‐Vale
Journal of Physiology, 2016
Effects of high EPA and high DHA fish oils on changes in signaling associated with protein metabolism induced by hindlimb suspension in rats
Gabriel Nasri Marzuca-Nassr, Kaio Fernando Vitzel, Luís Gustavo De Sousa, Gilson M. Murata, Amanda Rabello Crisma, Carlos Flores Rodrigues Junior, Phablo Abreu, Rosângela Pavan Torres, Jorge Mancini-Filho, Sandro M. Hirabara, Philip Newsholme, Rui Curi
Physiological Reports, 2016
Hematological and biochemical reference values for C57BL/6, Swiss Webster and BALB/c mice
Ed Wilson Santos, Dalila Cunha de Oliveira, Araceli Hastreiter, Graziela Batista da Silva, Jackeline Soares de Oliveira Beltran, Maristela Tsujita, Amanda Rabelo Crisma, Silvânia Meiry Peris Neves, Ricardo Ambrósio Fock, Primavera Borelli
Brazilian Journal of Veterinary Research and Animal Science, 2016
DNA methylation changes induced by a high-fat diet and fish oil supplementation in the skeletal muscle of mice
Catia L. Amaral, Amanda R. Crisma, Laureane N. Masi, Amanda R. Martins, Sandro M. Hirabara, Rui Curi
Journal of Nutrigenetics and Nutrigenomics, 2015
Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob)
Márcia Sanae Mizuno
World Journal of Gastroenterology, 2014
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells
Mercedes Martín-Rufián, Renata Nascimento-Gomes, Ana Higuero, Amanda R. Crisma, José A. Campos-Sandoval, María C. Gómez-García, Carolina Cardona, Tzuling Cheng, Carolina Lobo, Juan A. Segura, Francisco J. Alonso, Monika Szeliga, Jan Albrecht, Rui Curi, Javier Márquez, Alison Colquhoun, Ralph J. DeBerardinis, José M. Matés
Journal of Molecular Medicine, 2014
Malnutrition suppresses cell cycle progression of hematopoietic progenitor cells in mice via cyclin D1 down-regulation
Karina Nakajima, Amanda R. Crisma, Graziela B. Silva, Marcelo M. Rogero, Ricardo A. Fock, Primavera Borelli
Nutrition, 2014
Macadamia oil supplementation attenuates inflammation and adipocyte hypertrophy in obese mice
Edson A. Lima, Loreana S. Silveira, Laureane N. Masi, Amanda R. Crisma, Mariana R. Davanso, Gabriel I. G. Souza, Aline B. Santamarina, Renata G. Moreira, Amanda Roque Martins, Luis Gustavo O. de Sousa, Sandro M. Hirabara, Jose C. Rosa Neto
Mediators of Inflammation, 2014
Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro
V. A. Paschoal, M. A. R. Vinolo, A. R. Crisma, J. Magdalon, R. Curi
Lipids, 2013
High-fat diet blunts activation of the nuclear factor-κB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats
Maria C. Borges, Marco A.R. Vinolo, Amanda R. Crisma, Ricardo A. Fock, Primavera Borelli, Julio Tirapegui, Rui Curi, Marcelo M. Rogero
Nutrition, 2013
Sunflower oil supplementation has proinflammatory effects and does not reverse insulin resistance in obesity induced by high-fat diet in C57BL/6 mice
Laureane Nunes Masi, Amanda Roque Martins, José César Rosa Neto, Cátia Lira do Amaral, Amanda Rabello Crisma, Marco Aurélio Ramirez Vinolo, Edson Alves de Lima Júnior, Sandro Massao Hirabara, Rui Curi
Journal of Biomedicine and Biotechnology, 2012
Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice
Marco Aurélio Ramirez Vinolo, Hosana G. Rodrigues, William T. Festuccia, Amanda R. Crisma, Vitor S. Alves, Amanda R. Martins, Catia L. Amaral, Jarlei Fiamoncini, Sandro M. Hirabara, Fabio T. Sato, Ricardo A. Fock, Gabriella Malheiros, Marinilce F. dos Santos, Rui Curi
American Journal of Physiology Endocrinology and Metabolism, 2012
Expression of the P2X2 receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse
Márcia Sanae Mizuno
World Journal of Gastroenterology, 2012
Iron bioavailability from ferric pyrophosphate in rats fed with fructan-containing yacon (Smallanthus sonchifolius) flour
Alexandre Rodrigues Lobo, Maria Lucia Cocato, Primavera Borelli, Eduardo H.S. Gaievski, Amanda R. Crisma, Karina Nakajima, Eduardo Y. Nakano, Célia Colli
Food Chemistry, 2011
Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages
Marcelo Macedo Rogero, Primavera Borelli, Ricardo Ambrósio Fock, Maria Carolina Borges, Marco Aurélio Ramirez Vinolo, Rui Curi, Karina Nakajima, Amanda Rabello Crisma, Aline Domingas Ramos, Julio Tirapegui
Amino Acids, 2010
Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model
Ricardo Ambrósio FOCK, Marco Aurélio Ramirez VINOLO, Amanda Rabello CRISMA, Karina NAKAJIMA, Marcelo Macedo ROGERO, Primavera BORELLI
Journal of Nutritional Science and Vitaminology, 2008
Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration
Marco Aurélio Ramirez Vinolo, Amanda Rabello Crisma, Karina Nakajima, Marcelo Macedo Rogero, Ricardo Ambrósio Fock, Primavera Borelli
Nutrition Research, 2008

MOST CITED SCHOLAR PUBLICATIONS

Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice
MAR Vinolo, HG Rodrigues, WT Festuccia, AR Crisma, VS Alves, ...
American Journal of Physiology-Endocrinology and Metabolism 303 (2), E272-E282 , 2012
2012
Citations: 201
Hematological and biochemical reference values for C57BL/6, Swiss Webster and BALB/c mice
EW Santos, DC de OLIVEIRA, A Hastreiter, GB da SILVA, ...
Brazilian Journal of Veterinary Research and Animal Science 53 (2), 138-145 , 2016
2016
Citations: 186
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells
M Martín-Rufián, R Nascimento-Gomes, A Higuero, AR Crisma, ...
Journal of molecular medicine 92 (3), 277-290 , 2014
2014
Citations: 146
Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet
AR Martins, AR Crisma, LN Masi, CL Amaral, GN Marzuca-Nassr, ...
The journal of nutritional biochemistry 55, 76-88 , 2018
2018
Citations: 95
Chemical composition, cytotoxicity, and antibacterial activity of propolis from Africanized honeybees and three different Meliponini species
M Surek, MM Fachi, A de Fátima Cobre, FF de Oliveira, R Pontarolo, ...
Journal of Ethnopharmacology 269, 113662 , 2021
2021
Citations: 84
Palmitoleic acid (16: 1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes
MM Cruz, AB Lopes, AR Crisma, RCC de Sá, WMT Kuwabara, R Curi, ...
Lipids in health and disease 17 (1), 55 , 2018
2018
Citations: 64
Fish oil prevents changes induced by a high‐fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes
RDCC de Sá, AR Crisma, MM Cruz, AR Martins, LN Masi, CL do Amaral, ...
The Journal of physiology 594 (21), 6301-6317 , 2016
2016
Citations: 61
Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro
VA Paschoal, MAR Vinolo, AR Crisma, J Magdalon, R Curi
Lipids 48 (2), 93-103 , 2013
2013
Citations: 61
Sunflower oil supplementation has proinflammatory effects and does not reverse insulin resistance in obesity induced by high‐fat diet in C57BL/6 mice
LN Masi, AR Martins, JCR Neto, CL Amaral, AR Crisma, MAR Vinolo, ...
BioMed Research International 2012 (1), 945131 , 2012
2012
Citations: 53
Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model
RA Fock, MAR Vinolo, AR Crisma, K Nakajima, MM Rogero, P Borelli
Journal of nutritional science and vitaminology 54 (5), 371-377 , 2008
2008
Citations: 53
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
MR Davanso, AR Crisma, TT Braga, LN Masi, CL do Amaral, VNC Leal, ...
Clinical Science 135 (1), 19-34 , 2021
2021
Citations: 51
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice
LN Masi, AR Martins, AR Crisma, CL do Amaral, MR Davanso, ...
Scientific reports 7 (1), 3937 , 2017
2017
Citations: 51
Iron bioavailability from ferric pyrophosphate in rats fed with fructan-containing yacon (Smallanthus sonchifolius) flour
AR Lobo, ML Cocato, P Borelli, EHS Gaievski, AR Crisma, K Nakajima, ...
Food Chemistry 126 (3), 885-891 , 2011
2011
Citations: 50
Tributyrin attenuates metabolic and inflammatory changes associated with obesity through a GPR109A-dependent mechanism
FT Sato, YA Yap, AR Crisma, M Portovedo, GM Murata, SM Hirabara, ...
Cells 9 (9), 2007 , 2020
2020
Citations: 46
Prophylactic Supplementation of Bifidobacterium longum 5 1A Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway …
E Mendes, BG Acetturi, AM Thomas, FS Martins, AR Crisma, G Murata, ...
Frontiers in microbiology 8, 1732 , 2017
2017
Citations: 44
DNA methylation changes induced by a high-fat diet and fish oil supplementation in the skeletal muscle of mice
CL Amaral, AR Crisma, LN Masi, AR Martins, SM Hirabara, R Curi
Lifestyle Genomics 7 (4-6), 314-326 , 2015
2015
Citations: 40
Macadamia oil supplementation attenuates inflammation and adipocyte hypertrophy in obese mice
EA Lima, LS Silveira, LN Masi, AR Crisma, MR Davanso, GIG Souza, ...
Mediators of Inflammation 2014 (1), 870634 , 2014
2014
Citations: 37
Malnutrition suppresses cell cycle progression of hematopoietic progenitor cells in mice via cyclin D1 down-regulation
K Nakajima, AR Crisma, GB Silva, MM Rogero, RA Fock, P Borelli
Nutrition 30 (1), 82-89 , 2014
2014
Citations: 35
High-fat diet blunts activation of the nuclear factor-κB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats
MC Borges, MAR Vinolo, AR Crisma, RA Fock, P Borelli, J Tirapegui, ...
Nutrition 29 (2), 443-449 , 2013
2013
Citations: 31
Effects of high EPA and high DHA fish oils on changes in signaling associated with protein metabolism induced by hindlimb suspension in rats
GN Marzuca‐Nassr, KF Vitzel, LG De Sousa, GM Murata, AR Crisma, ...
Physiological reports 4 (18), e12958 , 2016
2016
Citations: 30

Amanda Rabello Crisma

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