Adrian Tibor Press

@uniklinikum-jena.de

Professor for Molecular Medicine of Life-Threatening Infection
Jena University Hospital

Adrian Tibor Press


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https://researchid.co/adrianpress

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Molecular Medicine, Biochemistry, Genetics and Molecular Biology, Biotechnology
48

Scopus Publications

1100

Scholar Citations

18

Scholar h-index

24

Scholar i10-index

Scopus Publications

  • Sodium thiosulfate attenuates liver injury in a rat model of sepsis by modulating ferroptosis and oxidative stress
    Andrei Otto Mitre, Ioana Baldea, Gabriela Adriana Filip, Raluca Maria Pop, Maria Adriana Neag, Bianca Mitre, Andrada Negoescu, Adrian Tibor Press, Alina Elena Parvu
    Scientific Reports, 2026
    Sepsis is a dysregulated immune response to infection that can present with a pro-inflammatory endotype in which the ischemia/reperfusion injury leads to excessive production of reactive oxygen species (ROS), inflammatory mediators and the activation of cell death mechanisms. Sodium thiosulfate (STS) is a hydrogen sulfide producing agent that could reduce ischemia/reperfusion injuries induced ROS, inflammation and cell death. We used the peritoneal contamination and infection model in adult rats to induce sepsis. Animals from the treatment groups received either Trolox, an antioxidant medication or STS in doses of 500mg/kg b.w. (STS500 group) or 1000mg/kg b.w. (STS1000 group). Additionally all rats received fluid resuscitation therapy, antibiotic therapy and analgesic treatment. After 48 h the rats were sacrificed and blood and liver samples collected for analysis. Both STS500 and STS1000 reduced overall the ROS production and improved antioxidant defence mechanisms. They also reduced inflammatory cytokines IL-6 and TNF-α levels. In liver samples STS reduced inflammatory alterations and ferroptosis but had little effect on pyroptosis. STS could be a potential treatment option is sepsis pro-inflammatory endotypes by improving the redox balance and inhibiting ferroptosis and inflammation.
  • Extrahepatic Gene Editing In Vivo Using Organic Solvent-Free Lipid Nanoparticles
    Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger
    Small, 2026
    Targeted therapy, which modifies genes and their expression, holds great promise for treating a variety of diseases, including cancer, inborn errors of metabolism, and acute and chronic inflammatory and infectious conditions. However, it also presents challenges related to RNA delivery, immune responses, side effects of delivery vectors, and the need for individualized formulations. To overcome these limitations, the choice of lipids and formulation processes might be re‐evaluated, with a focus on eliminating critical components, such as poly(ethylene glycol) (PEG) and ethanol. Thus, a purely water‐based formulation for lipid nanoparticles was developed, offering a material‐efficient, time‐saving process with high reproducibility. Initially, a stealth lipid containing poly(2‐methyl‐2‐oxazoline) (PMeOx) was used, and the formulation was later expanded to include approved lipids. These nanoparticles not only efficiently transfect primary human immune cells but also effectively deliver multiple nucleotides in CRISPR‐Cas9 applications. Moreover, an in vivo comparison revealed that the nanoparticles exhibited preferential transfection in extrahepatic tissues. This distinguishes them from conventional cholesterol‐rich lipid nanoparticles, which primarily target the liver regardless of the application route.
  • From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [68Ga]Ga-TEoS-DAZA
    Julia Greiser, Robert Drescher, Mitali Sonawane, Christian Kuehnel, Steffen Wiegand, et al.
    Journal of Nuclear Medicine, 2026
    Ga]Ga-TEoS-DAZA was shown to be a suitable hepatobiliary tracer using both mice and ostrich embryos as preclinical models; however, there were limits in translatability in both models because of a distinctly faster hepatic uptake and biliary excretion (mice) or a slower biliary excretion (ostrich embryo) compared with that in the human.
  • Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness
    Anna Kleyman, Walter Pisciotta, Charlotte Gaupp, Waqas Khaliq, Daniel Hofmaenner, David Brealey, Bernardo Bollen Pinto, Davide Tommaso Andreis, Mark Gerard Waugh, Miranda J. Melis, Muska Miller, Klea Mehmetaj, Michael Bauer, Adrian Press, Mervyn Singer
    Critical Care, 2025
    Background Sepsis-induced cardiomyopathy (SIM) is characterized by myocardial dysfunction, diminished catecholamine responsiveness and worse outcomes. Hypocholesterolemia is also a well-recognized prognosticator of poor outcomes in sepsis. In vitro physiology/pharmacology studies indicate that low cholesterol levels within the cardiomyocyte membrane regulate ß-adrenergic receptor activity. We therefore hypothesized that cardiomyocyte membrane cholesterol levels are reduced in sepsis and this contributes to SIM. Methods Cardiovascular biomarkers and plasma lipid profiles measured sequentially (6, 24 and 72 h) in a fluid-resuscitated rat model of fecal peritonitis were compared against those measured in 27 septic patients on Days 1–3 of ICU admission. In separate studies, rat hearts were excised at the same time points for measurement of cardiomyocyte membrane cholesterol and downstream adrenergic signaling. In a final study, the impact of a 15-hour infusion of cholesterol, either given as HDL-cholesterol or liposomal cholesterol, commencing at 6 h post-sepsis induction, on dobutamine responsiveness and cardiomyocyte membrane cholesterol levels was assessed. Results The magnitude of fall in stroke volume, rise in heart rate, plasma troponin and BNP, and fall in plasma HDL-cholesterol on ICU Day 1 in septic patients and at 6 h in the rat model all prognosticated for poor outcomes. In parallel, cardiomyocyte membrane cholesterol fell in the rats, more so in poor prognosis animals, with a blunted inotropic response to dobutamine, indicative of SIM. Cholesterol administration restored cardiomyocyte membrane cholesterol, dobutamine responsiveness and adrenergic signaling. Conclusions In a long-term rat model of sepsis, that parallels changes seen in septic patients, cardiomyocyte membrane cholesterol fell with associated decreases in catecholamine responsiveness. These features could be restored by cholesterol infusion, suggesting potential utility as a therapeutic.
  • Hepatobiliary PET with [68Ga]Ga-BP-IDA – preclinical evaluation and its translational potential for liver function monitoring
    Julia Greiser, Robert Drescher, Marta Pomraenke, Mitali Sonawane, Olga Perkas, Christian Kuehnel, Thomas Scholz, Sebastian Groeber, Thomas Weisheit, Adrian Press, Thomas Winkens, Nathalie Viohl, Anke Werner, Michael Bauer, Martin Freesmeyer
    Ejnmmi Research, 2025
    Background The aim of this study was to investigate the preclinical biodistribution and molecular pathway of [68Ga]Ga-BP-IDA and to evaluate its clinical suitability for quantitative monitoring of liver function during transarterial radioembolization (TARE) therapy of a hepatocellular carcinoma (HCC). Results [68Ga]Ga-BP-IDA undergoes hepatobiliary clearance, with uptake into hepatocytes via OATP1B1 and OATP1B3. [68Ga]Ga-BP-IDA exhibits demetallation in vivo but is nevertheless suitable for clinical application due to its rapid uptake into functional liver tissue. In a clinical case [68Ga]Ga-BP-IDA PET/CT allowed for differentiation of functional liver mass from cancerous tissue and enabled monitoring the effect on liver and tumor volume as well as on residual liver function after TARE therapy. Following TARE treatment, a reduction of the hepatic uptake rate was observed in both non-cancerous liver lobes, but was more pronounced in the right lobe, indicating a correlation to the higher non-targeted radiation dose from the TARE treatment in this lobe. [68Ga]Ga-BP-IDA PET/CT thus revealed additional information on liver function impairment which was not represented by CT-based volumetry alone. Conclusion [68Ga]Ga-BP-IDA PET/CT is a suitable tool for planning and monitoring TARE therapy of primary liver tumors and may complement the limits of volumetry-based methods with functional information about the liver.
  • Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48
    Muhammad Awais Afzal, Mohamed Ghait, Adeela Hussain, Anke Siegmund, Lorena Tuchscherr, Petra Babic, Adrian T. Press, Robert Hardt, Dominic Winter, Annekathrin Rödiger, Rebecca Schüle, Jens Fielitz, Michael Bauer, Christian Andreas Hübner
    Ebiomedicine, 2025
    BACKGROUND: Hereditary spastic paraplegia (HSP) denotes a heterogeneous group of neurodegenerative spastic gait disorders. Variants in SPG11 cause the most common autosomal recessive HSP also known as SPG11. The gene product Spatacsin interacts with the adaptor protein complex 5 (AP5). Because neurodegeneration in SPG11 is accompanied by marked neuro-inflammation, we hypothesised that Spatacsin may play a cell-autonomous role in pro-inflammatory cells. METHODS: Inflammasome activation was assessed in primary microglia and bone-marrow-derived-macrophages (BMDMs) from wild-type, Spg11, and Ap5z1 knockout (KO) mice and monocyte-derived-macrophages (MDMs) from patients with SPG11 mutations. Wild-type and Spg11 KO mice were used to study microglia activation and LPS-induced inflammatory responses in vivo. FINDINGS: We show that microglia activation is more pronounced in pre-symptomatic Spg11 KO compared with control mice following systemic lipopolysaccharide (LPS) challenge. Our subsequent studies demonstrate that the activation of the non-canonical inflammasome results in a stronger inflammatory response in primary microglia and BMDMs from Spg11 KO mice, while the canonical pathway is unaffected. These findings are also observed in MDMs isolated from patients carrying loss-of-function SPG11 mutations. In vivo, LPS triggers a much stronger inflammatory response and leads to drastically increased lethality in Spg11 KO mice. Mass spectrometry of activated BMDMs unveils a massive downregulation of AP5 subunits upon disruption of Spg11. Notably, the disruption of its ζ-subunit Ap5z1, which is associated with SPG48, also sensitises the non-canonical inflammasome. INTERPRETATION: Our findings suggest that a hyper-reactivity of the non-canonical inflammasome in innate immune cells contributes to neuro-inflammation in SPG11 and SPG48. FUNDING: Please see Acknowledgements.
  • LILRA5 Functions to Induce ROS Production on Innate Immune Cells
    Zuyi Fu, Matevž Rumpret, Irina Kube‐Golovin, Mykola Lyndin, Vera Solntceva, Yuxi Zhao, Anastasia Konieva, Na Liu, Adrian T. Press, Stefanie B. Flohé, Michael Bauer, Gunther Wennemuth, Bernhard B Singer, Alex J. McCarthy
    European Journal of Immunology, 2025
    Activating immune receptors provides mechanisms for phagocytes to elicit important effector functions that promote the killing of microbes. Leukocyte immunoglobulin‐like receptor A5 (LILRA5), an orphan immune receptor expressed by human phagocytes and co‐localising with FcRγ, remains poorly characterised. To address this, we developed a highly specific anti‐LILRA5 monoclonal antibody that has agonistic properties. We show LILRA5 expression on naïve monocytes and neutrophils, and that ligation of LILRA5 stimulates ROS production. While increased LILRA5 transcripts have been associated with sepsis, we also observed increased levels in patients with systemic infection but without sepsis complications. Ex vivo bacterial infection of whole blood did not alter surface LILRA5 expression, but LPS stimulation changed expression levels, indicating that surface LILRA5 expression is dynamic and likely regulated post‐transcriptionally, changing responses to different stimuli or over time. Soluble (s)LILRA5 was enhanced in sera from sepsis patients and in supernatants of monocytes that were LPS‐stimulated, indicating that shedding of LILRA5 from cell surfaces or that expression of sLILRA5 isoforms provides a mechanism to regulate surface LILRA5 expression levels. Finally, we show that altered surface LILRA5 expression influences LILRA5‐induced ROS production capacity. Thus, LILRA5 is a dynamically regulated activating receptor expressed on phagocytes that stimulates ROS production.
  • Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models
    Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press
    Pharmacological Research, 2025
    Sepsis is a life-threatening organ failure resulting from a poorly regulated infection response. Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. Although experimental studies correlated excretory liver functionality with immune performance and survival rates in sepsis, the proteins and pathways involved remain unclear. This study identified protein kinase C-α (PKCα) as a novel target for managing excretory liver function during sepsis. Using a preclinical murine sepsis model, we found that both PKCα knockout and the use of a PKCα-inhibitor midostaurin successfully restored liver function without hindering the host's response or ability to clear the pathogen, highlighting PKCα's vital role in excretory liver failure. In septic animals, both approaches significantly boosted survival rates. Midostaurin is the clinically approved active pharmaceutical ingredient in Rydapt, approved for the adjuvant treatment of FTL3-mutated AML. Here, it reduced plasma bile acids and related inflammation in those patients, opening a translational avenue for therapeutics in sepsis. Conclusively, our research underscores the significance of PKCα in controlling excretory liver function during inflammation. This suggests that targeting this protein could restore liver function without compromising the immune system, thereby decreasing sepsis mortality and supporting the recent paradigm that the liver is a hub for the host response to infection that might, in the future, result in novel host-directed therapies supporting the current state-of-the-art intensive care medicine in patients with sepsis-associated liver failure.
  • Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis
    Ritvik Mathur, Sara Elsafy, Adrian T. Press, Julian Brück, Mathias Hornef, Lukas Martin, Tobias Schürholz, Gernot Marx, Matthias Bartneck, Fabian Kiessling, Josbert Maarten Metselaar, Gert Storm, Twan Lammers, Alexandros Marios Sofias, Patrick Koczera
    ACS Nano, 2024
    Sepsis is characterized by a dysregulated immune response and is very difficult to treat. In the cecal ligation and puncture (CLP) mouse model, we show that nanomedicines can effectively alleviate systemic and local septic events by targeting neutrophils. Specifically, by decorating the surface of clinical-stage dexamethasone liposomes with cyclic arginine-glycine-aspartic acid (cRGD) peptides, we promote their engagement with neutrophils in the systemic circulation, leading to their prominent accumulation at primary and secondary sepsis sites. cRGD-targeted dexamethasone liposomes potently reduce immature circulating neutrophils and neutrophil extracellular traps in intestinal sepsis induction sites and the liver. Additionally, they mitigate inflammatory cytokines systemically and locally while preserving systemic IL-10 levels, contributing to lower IFN-γ/IL-10 ratios as compared to control liposomes and free dexamethasone. Our strategy addresses sepsis at the cellular level, illustrating the use of neutrophils both as a therapeutic target and as a chariot for drug delivery.
  • Nanoscale chemical characterization of secondary protein structure of F-Actin using mid-infrared photoinduced force microscopy (PiF-IR)
    Jesvin Joseph, Lukas Spantzel, Maryam Ali, Dijo Moonnukandathil Joseph, Sebastian Unger, Katharina Reglinski, Christoph Krafft, Anne-Dorothea Müller, Christian Eggeling, Rainer Heintzmann, Michael Börsch, Adrian T. Press, Daniela Täuber
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2024
    The recently developed photoinduced force microscopy for mid-infrared (PiF-IR) offers high spectral resolution in combination with surface sensitivity and a spatial resolution in the range of a few nanometers. Although PiF-IR has primarily been applied to polymer materials, this technology presents significant potential for the chemical characterization of cellular structures approaching single-molecule sensitivity. We applied PiF-IR to differently polymerized F-Actin samples finding general agreement with FTIR spectra from the same samples. Single PiF-IR spectra of F-Actin show variations in the amide I band spectral region, which is related to secondary protein structure. Local variations are also seen in PiF-IR hyperspectra in this region. Such high sensitivity is a necessary requirement for discriminating Actin organization into bundles and other networks in cells and tissue. We applied PiF-IR to mouse liver tissue ex vivo. Single-frequency PiF-IR scans at three different IR frequencies show significant variations in local contrast. However, the presence of other proteins and the unique spatial resolution of PiF-IR pose a challenge to interpreting and validating such data. Careful design of model systems and further theoretical understanding of PiF-IR data far from bulk averages are needed to fully unfold the potential of PiF-IR for high-resolution chemical investigation in the Life Sciences.
  • Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
    Na Liu, Mitali Sonawane, Oliver Sommerfeld, Carl-Magnus Svensson, Marc Thilo Figge, Reinhard Bauer, Sabine Juliane Bischoff, Michael Bauer, Marcin Filip Osuchowski, Adrian Tibor Press
    Frontiers in Immunology, 2024
  • Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage
    Howell Leung, Ling Xiong, Yueqiong Ni, Anne Busch, Michael Bauer, Adrian T. Press, Gianni Panagiotou
    Npj Biofilms and Microbiomes, 2023
  • Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs
    Hyeonsoo Bae, Marko Rodewald, Tobias Meyer-Zedler, Thomas W. Bocklitz, Gregor Matz, Bernhard Messerschmidt, Adrian T. Press, Michael Bauer, Orlando Guntinas-Lichius, Andreas Stallmach, Michael Schmitt, Juergen Popp
    Scientific Reports, 2023
  • Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
    Friederike Dellbrügge, Lena D. Jesse, Anna Medyukhina, Na Liu, Sophie Neugebauer, Markus Freißmuth, Stephanie Höppener, Marc T. Figge, Helen Morrison, Lars B. Riecken, Adrian T. Press
    Heliyon, 2023
  • Raman Spectroscopy Profiling of Splenic T-Cells in Sepsis and Endotoxemia in Mice
    Ibukun Elizabeth Osadare, Ling Xiong, Ignacio Rubio, Ute Neugebauer, Adrian T. Press, Anuradha Ramoji, Juergen Popp
    International Journal of Molecular Sciences, 2023
  • Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury
    Adrian T. Press, Luisa Ungelenk, Anna Medyukhina, Samantha A. Pennington, Sandor Nietzsche, Chunyi Kan, Amelie Lupp, Uta Dahmen, Rui Wang, Utz Settmacher, Reinhard Wetzker, Marc Thilo Figge, Mark G. Clemens, Michael Bauer
    Free Radical Biology and Medicine, 2023
  • RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
    Jessica Hoff, Ling Xiong, Tobias Kammann, Sophie Neugebauer, Julia M. Micheel, Nikolaus Gaßler, Michael Bauer, Adrian T. Press
    Cell Death and Disease, 2023
  • Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells
    WanLing Foo, Zoltán Cseresnyés, Carsten Rössel, Yingfeng Teng, Anuradha Ramoji, Mingzhe Chi, Walter Hauswald, Sophie Huschke, Stephanie Hoeppener, Jürgen Popp, Felix H. Schacher, Marek Sierka, Marc Thilo Figge, Adrian T. Press, Michael Bauer
    Biomaterials, 2023
  • Dysregulated Immune Response and Organ Dysfunction: Liver
    Adrian T. Press, Michael Bauer
    Lessons from the Icu, 2023
  • The immunological function of CXCR2 in the liver during sepsis
    Na Liu, Michael Bauer, Adrian T. Press
    Journal of Inflammation United Kingdom, 2022
  • The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation
    Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gaßler, Adrian T. Press
    Molecular Medicine, 2022
  • Author Correction: Cargo–carrier interactions significantly contribute to micellar conformation and biodistribution (NPG Asia Materials, (2017), 9, 10, (e444), 10.1038/am.2017.161)
    Adrian T. Press, Anuradha Ramoji, Moritz vd Lühe, Alexandra C. Rinkenauer, Jessica Hoff, Marianne Butans, Carsten Rössel, Christian Pietsch, Ute Neugebauer, Felix H. Schacher, Michael Bauer
    Npg Asia Materials, 2022
  • Automated multicolor mesoscopic imaging for the 3-dimensional reconstruction of fluorescent biomarker distribution in large tissue specimens
    Wanling Foo, Alexander Wiede, Sebastian Bierwirth, Rainer Heintzmann, Adrian T. Press, Walter Hauswald
    Biomedical Optics Express, 2022
  • Etiology–histomorphology–entity correlation in liver pathology: a narrative review
    Nikolaus Gassler, Adrian Press, Falk Rauchfuß, Bernhard Theis, Elke Kaemmerer
    Ame Medical Journal, 2022
  • Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data
    Bianca Hoffmann, Ruman Gerst, Zoltán Cseresnyés, WanLing Foo, Oliver Sommerfeld, Adrian T. Press, Michael Bauer, Marc Thilo Figge
    Photoacoustics, 2022
  • Poly(2-oxazoline) Homopolymers and Diblock Copolymers Containing Retinoate ω‑End Groups
    Leanne M. Stafast, Christine Weber, Maren T. Kuchenbrod, Stephanie Hoeppener, Mira Behnke, Stephanie Schubert, Klea Mehmetaj, Adrian T. Press, Michael Bauer, Ulrich S. Schubert
    ACS Applied Polymer Materials, 2022
  • The Many Roles of Cholesterol in Sepsis A Review
    Daniel A. Hofmaenner, Anna Kleyman, Adrian Press, Michael Bauer, Mervyn Singer
    American Journal of Respiratory and Critical Care Medicine, 2022
  • Automated multicolour mesoscopic imaging for the 3-dimensional reconstruction of fluorescent biomarker distribution in large tissue specimens
    Optics Infobase Conference Papers, 2022
  • Intracellularly released cholesterol from polymer-based delivery systems alters cellular responses to pneumolysin and promotes cell survival
    Tobias Kammann, Jessica Hoff, Ilknur Yildirim, Blerina Shkodra, Tina Müller, Christine Weber, Markus H. Gräler, Ulrich A. Maus, James C. Paton, Mervyn Singer, Anja Traeger, Ulrich S. Schubert, Michael Bauer, Adrian T. Press
    Metabolites, 2021
  • Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
    Yunxia Ma, Miljana Nenkov, Yuan Chen, Adrian T Press, Elke Kaemmerer, Nikolaus Gassler
    World Journal of Hepatology, 2021
  • Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis
    Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer
    EMBO Molecular Medicine, 2021
  • Biochemical analysis of leukocytes after in vitro and in vivo activation with bacterial and fungal pathogens using raman spectroscopy
    Aikaterini Pistiki, Anuradha Ramoji, Oleg Ryabchykov, Daniel Thomas-Rüddel, Adrian T. Press, Oliwia Makarewicz, Evangelos J. Giamarellos-Bourboulis, Michael Bauer, Thomas Bocklitz, Jürgen Popp, Ute Neugebauer
    International Journal of Molecular Sciences, 2021
  • Controlled release of the α-tocopherol-derived metabolite α-13′-carboxychromanol from bacterial nanocellulose wound cover improves wound healing
    Jessica Hoff, Berit Karl, Jana Gerstmeier, Uwe Beekmann, Lisa Schmölz, Friedemann Börner, Dana Kralisch, Michael Bauer, Oliver Werz, Dagmar Fischer, Stefan Lorkowski, Adrian T. Press
    Nanomaterials, 2021
  • Stealth Effect of Short Polyoxazolines in Graft Copolymers: Minor Changes of Backbone End Group Determine Liver Cell-Type Specificity
    Irina Muljajew, Sophie Huschke, Anuradha Ramoji, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Wanling Foo, Jürgen Popp, Marc Thilo Figge, Christine Weber, Michael Bauer, Ulrich S. Schubert, Adrian T. Press
    ACS Nano, 2021
  • In vivo coherent anti-Stokes Raman scattering microscopy reveals vitamin A distribution in the liver
    Marko Rodewald, Hyeonsoo Bae, Sophie Huschke, Tobias Meyer‐Zedler, Michael Schmitt, Adrian Tibor Press, Stephanie Schubert, Michael Bauer, Juergen Popp
    Journal of Biophotonics, 2021
  • Characterization of a library of vitamin A-functionalized polymethacrylate-based nanoparticles for siRNA delivery
    Paul Klemm, Sophie Huschke, Marko Rodewald, Nadia Ehteshamzad, Mira Behnke, Xinyue Wang, Gizem Cinar, Ivo Nischang, Stephanie Hoeppener, Christine Weber, Adrian T. Press, Christiane Höppener, Tobias Meyer, Volker Deckert, Michael Schmitt, Jürgen Popp, Michael Bauer, Stephanie Schubert
    Polymer Chemistry, 2021
  • Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis
    Oliver Sommerfeld, Anna Medyukhina, Sophie Neugebauer, Mohamed Ghait, Svenja Ulferts, Amelie Lupp, Rainer König, Reinhard Wetzker, Stefan Schulz, Marc Thilo Figge, Michael Bauer, Adrian T. Press
    Molecular Therapy, 2021
  • Formulation of liver-specific PLGA-dy-635 nanoparticles loaded with the protein kinase C inhibitor bisindolylmaleimide i
    Blerina Shkodra, Adrian T. Press, Antje Vollrath, Ivo Nischang, Stephanie Schubert, Stephanie Hoeppener, Dorothee Haas, Christoph Enzensperger, Marc Lehmann, Petra Babic, Kay Jovana Benecke, Anja Traeger, Michael Bauer, Ulrich S. Schubert
    Pharmaceutics, 2020
  • Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells
    Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, Joachim H. Clement, Thomas Ernst, Ulrich S. Schubert, Jana Wotschadlo, Marc Lehmann, Christoph Enzensperger, Michael Bauer, Andreas Hochhaus
    Molecular Therapy Oncolytics, 2020
  • Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice
    Barbara Schaarschmidt, Sebastian Vlaic, Anna Medyukhina, Sophie Neugebauer, Sandor Nietzsche, Falk A. Gonnert, Jürgen Rödel, Mervyn Singer, Michael Kiehntopf, Marc Thilo Figge, Ilse D. Jacobsen, Michael Bauer, Adrian T. Press
    Theranostics, 2018
  • Fast simultaneous assessment of renal and liver function using polymethine dyes in animal models of chronic and acute organ injury
    A. T. Press, M. J. Butans, T. P. Haider, C. Weber, S. Neugebauer, M. Kiehntopf, U. S. Schubert, M. G. Clemens, M. Bauer, A. Kortgen
    Scientific Reports, 2017
  • Uptake of Retinoic Acid-Modified PMMA Nanoparticles in LX-2 and Liver Tissue by Raman Imaging and Intravital Microscopy
    Turgay Yildirim, Christian Matthäus, Adrian T. Press, Stephanie Schubert, Michael Bauer, Jürgen Popp, Ulrich S. Schubert
    Macromolecular Bioscience, 2017
  • Cargo–carrier interactions significantly contribute to micellar conformation and biodistribution
    Adrian T Press, Anuradha Ramoji, Moritz vd Lühe, Alexandra C Rinkenauer, Jessica Hoff, Marianne Butans, Carsten Rössel, Christian Pietsch, Ute Neugebauer, Felix H Schacher, Michael Bauer
    Npg Asia Materials, 2017
  • Short-term treatment with taurolidine is associated with liver injury
    René Fahrner, Anika Möller, Adrian T. Press, Andreas Kortgen, Michael Kiehntopf, Falk Rauchfuss, Utz Settmacher, Alexander S. Mosig
    BMC Pharmacology Toxicology, 2017
  • A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo
    Adrian T. Press, Luisa Ungelenk, Alexandra C. Rinkenauer, Marko Gröger, Frank Lehmann, Alexander Mosig, Ulrich S. Schubert, Mark G. Clemens, Michael Bauer
    Journal of Biophotonics, 2016
  • Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo
    Alexandra C. Rinkenauer, Adrian T. Press, Martin Raasch, Christian Pietsch, Simon Schweizer, Simon Schwörer, Karl L. Rudolph, Alexander Mosig, Michael Bauer, Anja Traeger, Ulrich S. Schubert
    Journal of Controlled Release, 2015
  • Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles
    Adrian T. Press, Anja Traeger, Christian Pietsch, Alexander Mosig, Michael Wagner, Mark G. Clemens, Nayla Jbeily, Nicole Koch, Michael Gottschaldt, Nicolas Bézière, Volodymyr Ermolayev, Vasilis Ntziachristos, Jürgen Popp, Michael M. Kessels, Britta Qualmann, Ulrich S. Schubert, Michael Bauer
    Nature Communications, 2014
  • The liver in sepsis: Patterns of response and injury
    Michael Bauer, Adrian T. Press, Michael Trauner
    Current Opinion in Critical Care, 2013

RECENT SCHOLAR PUBLICATIONS

  • Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles
    M Streiber, N Liu, L Simon, F Adermann, V Bachmann, L Gath, ...
    Small 22 (27), e11489 , 2026
    2026
    Citations: 1
  • 68GA-TRACERS FOR IMAGING OF THE HEPATOBILIARY FUNCTION
    J Greiser, R Drescher, A Werner, C Kühnel, T Ross, FM Bengel, A Press, ...
    EANM Innovation 2, 100097 , 2026
    2026
  • From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [68Ga] Ga-TEoS-DAZA
    J Greiser, R Drescher, M Sonawane, C Kuehnel, S Wiegand, O Perkas, ...
    Journal of Nuclear Medicine , 2026
    2026
    Citations: 1
  • Sodium thiosulfate attenuates liver injury in a rat model of sepsis by modulating ferroptosis and oxidative stress
    AO Mitre, I Baldea, GA Filip, RM Pop, MA Neag, B Mitre, A Negoescu, ...
    Scientific Reports , 2025
    2025
  • Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48
    MA Afzal, M Ghait, A Hussain, A Siegmund, L Tuchscherr, P Babic, ...
    Ebiomedicine 121 , 2025
    2025
    Citations: 1
  • Hepatobiliary PET with [ 68 Ga]Ga-BP-IDA – preclinical evaluation and its translational potential for liver function monitoring
    J Greiser, R Drescher, M Pomraenke, M Sonawane, O Perkas, C Kuehnel, ...
    EJNMMI research 15 (1), 128 , 2025
    2025
  • LILRA5 Functions to Induce ROS Production on Innate Immune Cells
    Z Fu, M Rumpret, I Kube‐Golovin, M Lyndin, V Solntceva, Y Zhao, ...
    European Journal of Immunology 55 (10), e70079 , 2025
    2025
    Citations: 2
  • Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness
    A Kleyman, W Pisciotta, C Gaupp, W Khaliq, D Hofmaenner, D Brealey, ...
    Critical Care 29 (1), 399 , 2025
    2025
    Citations: 3
  • PKCalpha-PlIOSPHATASE FEEDBACK LOOPS IN SEPSIS-ASSOCIATED LIVER FAILURE: MOLECULAR INSIGHTS
    A Gomeniuk, L Xiong, CM Svensson, MT Figge, M Bauer, AT Press
    SHOCK 64 (3 S), S11-S11 , 2025
    2025
  • PKCalpha-PHOSPHATASE FEEDBACK LOOPS IN HEPATOCYTES: A THERAPEUTIC LINK TO SEPSIS-ASSOCIATED LIVER FAILURE
    L Xiong, A Gomeniuk, N Liu, M Bauer, AT Press
    SHOCK 64 (3 S), S41-S41 , 2025
    2025
  • COMPETITIVE CXCR2 ANTAGONISM RESTORES NEUTROPHIL'S ABILITY TO CONTROL THE HOST RESPONSE TO INFECTION IN SURVIVAL AND SEVERITY STRATIFIED POLYMICROBIAL MOUSE SEPSIS
    N Liu, J Halbauer, M Bauer, AT Press
    SHOCK 64 (3 S), S19-S20 , 2025
    2025
  • Die Rolle von Cholesterol bei systemischen Infektionen von Neugeborenen–eine prospektive Studie am Universitätsklinikum Jena
    D Beyer, O Sommerfeld, H Proquitté, AT Press
    Zeitschrift für Geburtshilfe und Neonatologie 229 (03), KV-018 , 2025
    2025
  • Sterol therapy
    M Singer, A Kleyman, A Press, M Bauer
    US Patent App. 18/688,602 , 2025
    2025
  • Leukocyte immunoglobulin-like receptor A5 functions to induce ROS production on innate immune cells
    Z Fu, M Rumpret, I Kube-Golovin, M Lyndin, V Solntceva, Y Zhao, ...
    bioRxiv, 2025.03. 16.643524 , 2025
    2025
  • Bildgebung der Leber-(dys)-funktion mit hepatobiliären Gallium-68-Tracern
    J Greiser, R Drescher, T Winkens, C Kühnel, M Pomraenke, A Press, ...
    Nuklearmedizin-NuclearMedicine 64 (01), L04 , 2025
    2025
  • Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models
    L Xiong, D Beyer, N Liu, T Lehmann, S Neugebauer, S Schaeuble, ...
    Pharmacological Research 212, 107581 , 2025
    2025
    Citations: 4
  • Prognostic value of admission H3. 1 nucleosome levels in sepsis-associated acute kidney injury: a secondary analysis of the SISPCT randomised clinical trial
    C Neumann, F Bloos, TTW Hla, T Bygott, H Bogatsch, M Kiehntopf, ...
    medRxiv, 2025.01. 28.25321238 , 2025
    2025
    Citations: 1
  • Solvent-Free Lipid Nanoparticle Formulation Enables In Vivo Gene Editing Predominantly in Extrahepatic Tissues
    M Streiber, N Liu, L Simon, F Adermann, V Bachmann, S Hoeppener, ...
    Available at SSRN 5200072 , 2024
    2024
  • Neutrophil hitchhiking enhances liposomal dexamethasone therapy of sepsis
    R Mathur, S Elsafy, AT Press, J Brück, M Hornef, L Martin, T Schürholz, ...
    ACS nano 18 (42), 28866-28880 , 2024
    2024
    Citations: 26
  • Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
    N Liu, M Sonawane, O Sommerfeld, CM Svensson, MT Figge, R Bauer, ...
    Frontiers in Immunology 15, 1432307 , 2024
    2024
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • The many roles of cholesterol in sepsis: a review
    DA Hofmaenner, A Kleyman, A Press, M Bauer, M Singer
    American journal of respiratory and critical care medicine 205 (4), 388-396 , 2022
    2022
    Citations: 149
  • The liver in sepsis: patterns of response and injury
    M Bauer, AT Press, M Trauner
    Current opinion in critical care 19 (2), 123-127 , 2013
    2013
    Citations: 127
  • The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation
    D Beyer, J Hoff, O Sommerfeld, A Zipprich, N Gaßler, AT Press
    Molecular Medicine 28 (1), 84 , 2022
    2022
    Citations: 119
  • Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles
    AT Press, A Traeger, C Pietsch, A Mosig, M Wagner, MG Clemens, ...
    Nature communications 5 (1), 5565 , 2014
    2014
    Citations: 72
  • Targeting complement C5a receptor 1 for the treatment of immunosuppression in sepsis
    O Sommerfeld, A Medyukhina, S Neugebauer, M Ghait, S Ulferts, A Lupp, ...
    Molecular Therapy 29 (1), 338-346 , 2021
    2021
    Citations: 52
  • Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo
    AC Rinkenauer, AT Press, M Raasch, C Pietsch, S Schweizer, ...
    Journal of Controlled Release 216, 158-168 , 2015
    2015
    Citations: 51
  • Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
    Y Ma, M Nenkov, Y Chen, AT Press, E Kaemmerer, N Gassler
    World Journal of Hepatology 13 (11), 1512 , 2021
    2021
    Citations: 46
  • Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage
    H Leung, L Xiong, Y Ni, A Busch, M Bauer, AT Press, G Panagiotou
    npj Biofilms and Microbiomes 9 (1), 35 , 2023
    2023
    Citations: 40
  • Controlled release of the α-tocopherol-derived metabolite α-13′-carboxychromanol from bacterial nanocellulose wound cover improves wound healing
    J Hoff, B Karl, J Gerstmeier, U Beekmann, L Schmölz, F Börner, D Kralisch, ...
    Nanomaterials 11 (8), 1939 , 2021
    2021
    Citations: 35
  • Stealth effect of short polyoxazolines in graft copolymers: Minor changes of backbone end group determine liver cell-type specificity
    I Muljajew, S Huschke, A Ramoji, Z Cseresnyés, S Hoeppener, I Nischang, ...
    ACS nano 15 (7), 12298-12313 , 2021
    2021
    Citations: 35
  • Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis
    AT Press, P Babic, B Hoffmann, T Müller, W Foo, W Hauswald, J Benecke, ...
    EMBO molecular medicine 13 (10), EMMM202114436 , 2021
    2021
    Citations: 34
  • Cargo–carrier interactions significantly contribute to micellar conformation and biodistribution
    AT Press, A Ramoji, AC Rinkenauer, J Hoff, M Butans, C Rössel, ...
    NPG Asia Materials 9 (10), e444-e444 , 2017
    2017
    Citations: 34
  • Biochemical analysis of leukocytes after in vitro and in vivo activation with bacterial and fungal pathogens using Raman spectroscopy
    A Pistiki, A Ramoji, O Ryabchykov, D Thomas-Rüddel, AT Press, ...
    International journal of molecular sciences 22 (19), 10481 , 2021
    2021
    Citations: 27
  • Neutrophil hitchhiking enhances liposomal dexamethasone therapy of sepsis
    R Mathur, S Elsafy, AT Press, J Brück, M Hornef, L Martin, T Schürholz, ...
    ACS nano 18 (42), 28866-28880 , 2024
    2024
    Citations: 26
  • RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
    J Hoff, L Xiong, T Kammann, S Neugebauer, JM Micheel, N Gaßler, ...
    Cell death & disease 14 (4), 275 , 2023
    2023
    Citations: 23
  • Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs
    H Bae, M Rodewald, T Meyer-Zedler, TW Bocklitz, G Matz, ...
    Scientific reports 13 (1), 13779 , 2023
    2023
    Citations: 18
  • Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury
    AT Press, L Ungelenk, A Medyukhina, SA Pennington, S Nietzsche, ...
    Free Radical Biology and Medicine 204, 151-160 , 2023
    2023
    Citations: 18
  • Short-term treatment with taurolidine is associated with liver injury
    R Fahrner, A Möller, AT Press, A Kortgen, M Kiehntopf, F Rauchfuss, ...
    BMC Pharmacology and Toxicology 18 (1), 61 , 2017
    2017
    Citations: 18
  • The immunological function of CXCR2 in the liver during sepsis
    N Liu, M Bauer, AT Press
    Journal of Inflammation 19 (1), 23 , 2022
    2022
    Citations: 17
  • Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice
    B Schaarschmidt, S Vlaic, A Medyukhina, S Neugebauer, S Nietzsche, ...
    Theranostics 8 (14), 3766 , 2018
    2018
    Citations: 17