The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals A. I. Israpilova, A. M. Dzhafarova, A. A. Adieva, G. M. Abakarov, N. O. Guseynova, U. Y. Khalimbekova, M. D. Astaeva, K. S. Bekshokov South of Russia Ecology Development, 2024 The purpose of this work was to study the influence of new synthesized organotellurium compounds (TOCs) on the intensity of oxidative processes in the body of mammals – in this case, the blood and liver of rats.The experiments were performed on white outbred rats, which were given a single dose of various TOC derivatives (0.01 g/kg). The next day, the animals were decapitated, blood was collected and the liver was isolated. The content of products of oxidative modification of lipids and proteins, as well as the low molecular weight antioxidant glutathione, was determined in blood plasma, erythrocytes and liver homogenate.It was found that all TOC derivatives studied significantly increase the intensity of lipid peroxidation in erythrocytes and hepatocytes, as evidenced by a multiple increase in the concentration of malondialdehyde (MDA) in them. At the same time, TOC suppresses the levels of oxidative damage to liver proteins, which is expressed in a significant decrease in the content of carbonyl groups. A study of glutathione content in the rat erythrocytes showed the absence of any significant effects of TOS on this antioxidant in erythrocytes.However, changes in its concentration were found in the liver, which depend on the nature of TOS (for TOS1 and TOS3 a decrease and for TOS2 a slight increase). Newly synthesized TOC demonstrate pronounced prooxidant properties, significantly increasing the intensity of oxidative processes in lipids, which makes them promising agents for antibacterial, antiviral and antitumor therapy.
New Syntheses of Cycloalka[c]pyridine-3-carboxamide and -carbonitrile Derivatives I. V. Dyachenko, V. D. Dyachenko, P. V. Dorovatovskii, V. N. Khrustalev, G. M. Abakarov, V. G. Nenajdenko Russian Journal of Organic Chemistry, 2023 Abstract Nicotinamide and nicotinonitrile derivatives containing a C5–C7-cycloalkane ring fused to the C4–C5 bond were synthesized via Knoevenagel condensation, nucleophilic vinylic substitution (SNVin), and alkylation. The structure of (1-amino-5-phenyl-5,6,7,8-tetrahydrothieno[2,3-c]isoquinolin-2-yl)(phenyl)methanone was determined by X-ray analysis.
New Derivatives of (Carbamoselenoyl)acetic Acid for the Synthesis of Functionally Substituted Selenazoles I. V. Dyachenko, V. D. Dyachenko, G. M. Abakarov, V. G. Nenajdenko Russian Journal of Organic Chemistry, 2021 New reagents for the synthesis of substituted selenazoles, 3-amino-N-cyclopropyl-3-selanylidenepropanamide and methyl 3-amino-3-selanylidenepropanoate, were obtained by reactions of 2-cyano-N-cyclopropylacetamide and methyl 2-cyanoacetate with hydrogen selenide. The structure of the products was confirmed by IR, 1H and 13C NMR, and mass spectra.
Cytotoxicity and antiviral activity of tellurium derivatives in cells infected with herpes simplex virus and cytomegalovirus in vitro A. A. Adieva, R. R. Klimova, G. M. Abakarov, K. S. Bekshokov, N. E. Fedorova, D. K. Omarova, A. A. Kushch, S. A. Dzhamalova, A. M. Khalimbekova, A. R. Guseynova South of Russia Ecology Development, 2021 Aim . To carry out a comparative analysis of the cytotoxic and antiviral properties of synthesized tellurium derivatives in model cellular systems of infections caused by herpes simplex virus and cytomegalovirus. Material and Methods . 4 organo‐tellurium compounds were studied using primary and continuous cell cultures in various infection schemes. Results . For each biological model studied, different thresholds of cytotoxicity concentration (TCD50 acute CC50 and CD50 CC50) were identified. Tellurium derivatives with methoxyphenyl and ethoxyphenyl ethene exhibit virus‐neutralizing activity, preventing the penetration of herpes simplex virus virions into sensitive cells. HTI (SI selectivity index) for these compounds was 84 and 77, respectively. Conclusion . The manifestation of the cytotoxic effect of all tellurium‐containing organic compounds for transplanted cells lies in a lower concentration than for primary cells. The data obtained in the analysis of antiviral activity showed that the derivatives have therapeutic properties against HSV infection in cell culture.
