Sex-Specific Differences in Post-Load Insulin Dynamics Are Independent of BMI-Based Adiposity and BIA-Derived Body Composition and Pubertal Stage in Adolescents with Obesity Anelise Sonza, Aline Faquin, Graziano Grugni, Adele Bondesan, Diana Caroli, Laura Abbruzzese, Alessandro Sartorio Journal of Clinical Medicine, 2026 Background: Sex-related differences in insulin sensitivity during adolescence remain incompletely understood, particularly in the context of obesity. Whether these differences reflect variations in basal insulin resistance or dynamic insulin responses remains unclear. Objective: To investigate sex differences in glucose and insulin responses during the oral glucose tolerance test (OGTT) and to explore mechanisms underlying potential dissociation between glycemic and insulinemic profiles. Methods: A cross-sectional analysis of 753 adolescents with obesity who underwent a standard oral glucose tolerance test (OGTT). Plasma glucose and insulin were measured at fasting and at 30, 60, 90, and 120 min. Mixed-effects models were used to examine glucose and insulin trajectories over time, including sex-by-time interactions, and to adjust for body mass index standard deviation score (BMI_SDS), pubertal stage (Tanner), metabolic syndrome (MetS), and body composition (resistance index). Multiple linear regression models were fitted to assess associations of sex with HOMA-IR, HOMA-β, total area under the curve (AUC), and phase-specific insulin AUCs. Results: Glucose trajectories during OGTT were similar between sexes, with no significant sex or sex-by-time interaction effects after adjustment. In contrast, insulin trajectories differed significantly by sex (sex-by-time interaction β = −0.10, p < 0.001). Boys exhibited higher baseline insulin levels and greater total insulin exposure (β = −11.2, p < 0.001), independent of BMI_SDS, pubertal stage, MetS, and body composition. Sex differences were sustained across all OGTT phases. HOMA-IR did not differ by sex, whereas HOMA-β showed a sex-related difference. BMI was positively associated with both basal and dynamic insulin measures. Conclusions: In adolescents with obesity, sex differences are characterized by altered dynamic insulin responses rather than differences in glycemic control. Boys exhibit greater compensatory insulin exposure during glucose challenge, independent of BMI-based adiposity, BIA-derived body composition and pubertal development.
Understanding the burden of endocrine and metabolic disorders in Prader-Willi syndrome: data from the Italian registry Graziano Grugni, Adele Rocchetti, Carmen Bucolo, Raffaele Buganza, Giorgia Buoncuore, Annamaria Colao, Domenico Corica, Antonino Crinò, Francesca Dassie, Luisa de Sanctis, Maurizio Delvecchio, Francesca Di Candia, Maria Felicia Faienza, Danilo Fintini, Donatella Greco, Laura Guazzarotti, Valentina Lo Preiato, Pietro Maffei, Michela Mariani, Enza Mozzillo, Uberto Pagotto, Roberta Pajno, Giuseppa Patti, Irene Rutigliano, Marco Salvatore, Alessandro Sartorio, Emanuela Scarano, Sofia Siena, Gianluca Tamaro, Gianluca Tornese, Rossella Vitale, Malgorzata Wasniewska, Giuseppe Zampino, Paola Torreri, Mohamad Maghnie Journal of Endocrinological Investigation, 2026
Correction: Understanding the burden of endocrine and metabolic disorders in Prader-Willi syndrome: data from the Italian registry (Journal of Endocrinological Investigation, (2026), 10.1007/s40618-026-02832-4) Graziano Grugni, Adele Rocchetti, Carmen Bucolo, Raffaele Buganza, Giorgia Buoncuore, Annamaria Colao, Domenico Corica, Antonino Crinò, Francesca Dassie, Luisa de Sanctis, Maurizio Delvecchio, Francesca Di Candia, Maria Felicia Faienza, Danilo Fintini, Donatella Greco, Laura Guazzarotti, Valentina Lo Preiato, Pietro Maffei, Michela Mariani, Enza Mozzillo, Uberto Pagotto, Roberta Pajno, Giuseppa Patti, Irene Rutigliano, Marco Salvatore, Alessandro Sartorio, Emanuela Scarano, Sofia Siena, Gianluca Tamaro, Gianluca Tornese, Rossella Vitale, Malgorzata Wasniewska, Giuseppe Zampino, Paola Torreri, Mohamad Maghnie Journal of Endocrinological Investigation, 2026
Quality of Life in Short Stature: Comparisons Between Normal Variants Short-Statured and Normal-Statured Children and Adolescents and Agreement with Their Parents Anna Guerrini Usubini, Nicoletta Marazzi, Laura Abbruzzese, Adele Bondesan, Graziano Grugni, Gianluca Castelnuovo, Alessandro Sartorio Healthcare Switzerland, 2025 Background/Objectives: This study aimed to evaluate quality of life in children and adolescents with normal variants of short stature compared to age- and sex-matched individuals with normal stature and to assess the agreement between children/adolescents-reported and parent-reported outcomes. Methods: A total of 65 child–parent dyads were enrolled, including 29 children and adolescents with short stature (15 males, 14 females; mean age: 11.2 + 2.0 years; mean height standard deviation score, HSDS: −2.10 + 0.57) and 36 children and adolescents with normal stature (19 males, 17 females; mean age: 11.3 + 1.93 years; mean HSDS: 0.56 + 0.78). Quality of life was assessed using the Quality of Life in Short Stature Youth (QoLISSY) questionnaire. Statistical analyses included independent samples t-tests, and effect sizes were computed using Cohen’s d. Results: Among short-statured children and adolescents, no significant correlations were found between HSDS and all domains of quality of life. Short-statured children and adolescents exhibited significantly lower QoL across all domains compared to their normal-statured peers. Coping was higher in children and adolescents with short stature compared to their peers of normal stature. Similarly, parents of short-statured children and adolescents perceived a lower QoL for their sons and daughters and reported greater concern about the future and a more perceived personal impact than parents of normal-statured children and adolescents. No statistically significant differences were found between sons/daughters and parent reports, indicating a relatively high level of agreement in quality of life (QoL) perceptions. Conclusions: These findings underscore the psychosocial impact of short stature and highlight the importance of incorporating both child and parent perspectives in the clinical assessment.
Assessing Metabolic Syndrome Risk in Children and Adolescents with Prader–Willi Syndrome: A Comparison of Index Performance Graziano Grugni, Fiorenzo Lupi, Mirko Bonetti, Sarah Bocchini, Carmen Bucolo, Domenico Corica, Antonino Crinò, Maria Felicia Faienza, Danilo Fintini, Maria Rosaria Licenziati, Mohamad Maghnie, Enza Mozzillo, Roberta Pajno, Giuseppe Zampino, Alessandro Sartorio, Giorgio Radetti Journal of Clinical Medicine, 2025 Background: Currently, there is a lack of data regarding the reliability of different anthropometric, instrumental, and biochemical indexes in detecting metabolic syndrome (MetS) in pediatric patients with Prader–Willi syndrome (PWS). Therefore, this study aimed to compare the accuracy of different indices to identify the simplest and most accurate predictor of MetS in this at-risk population. Methods: We conducted a multicenter study involving 124 children and adolescents with PWS (61 males and 63 females), aged 13.6 ± 3.7 years. For each participant, we assessed all components of MetS, defined according to either the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study or the International Diabetes Federation (IDF) criteria, based on age. The following indexes were calculated: Body Mass Index (BMI), BMI standard deviation score (BMI-SDS), tri-ponderal mass index, body mass fat index, fat mass index, fat-free mass index, body shape index, visceral adiposity index, waist-to-height ratio, cardiometabolic index, total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio, and triglycerides/HDL-C (TG/HDL-C) ratio. Results: MetS was identified in 24 subjects (9 females and 15 males), representing 19.4% of the sample. When comparing the receiver operating characteristic (ROC) curves, the TG/HDL-C ratio and cardiometabolic index demonstrated significantly better performance than the other indices in detecting MetS, with no difference between the two. As a result, we focused on the TG/HDL-C ratio since it is the simplest measure, requiring no additional anthropometric data compared to the cardiometabolic index. Additionally, applying age- and gender-specific thresholds can further improve its accuracy. Conclusions: The TG/HDL-C ratio, which requires only two standard biochemical markers, provides the same accuracy as more complex indexes in detecting MetS in children and adolescents with PWS, making it the optimal predictor for MetS in this population.
Comparison of Body Composition, Basal Metabolic Rate and Metabolic Outcomes of Adults with Prader-Willi Syndrome and Age- and BMI-Matched Patients with Essential Obesity Stefano Lazzer, Alessandro Gatti, Mattia D’Alleva, Lara Mari, Simone Zaccaron, Jacopo Stafuzza, Enrico Rejc, Adele Bondesan, Diana Caroli, Francesca Frigerio, Laura Abbruzzese, Enrica Ventura, Graziano Grugni, Alessandro Sartorio Journal of Clinical Medicine, 2025 Background/Objectives: This study compared metabolic syndrome (MetS) features in patients with Prader-Willi syndrome (PWS) to those in age-, BMI-, and gender-matched subjects with essential obesity (EOB). Methods: Thirty-two PWS patients (23 females, 9 males; median age 31.6 years; BMI 42.0 kg/m2) underwent several assessments, including anthropometric measurements, body composition via bio-impedance analysis, basal metabolic rate (BMR) using indirect calorimetry, and blood sampling. Results: Their data were compared to a matched EOB group (23 females, 9 males; median age 31.4 years; BMI 43.5 kg/m2). The study groups (PWS and EOB) were subsequently divided into two subgroups based on the International Diabetes Federation criteria for the definition of MetS. Results showed that individuals with PWS had significantly lower (p < 0.001) body weight (BW, −20.9%), height (−8.9%), fat-free mass (FFM, −23.5%), and fat mass (FM, −19.2%) in absolute terms compared to EOB subjects. However, the relative percentages of FFM and FM were similar. Absolute BMR was 25.5% (p < 0.001) lower in the PWS group; however, this difference disappeared when adjusted for FFM or body weight (BW). Metabolic outcomes were broadly similar between the groups, except for higher fasting glucose (+7.3%) and HbA1c levels (+7.9%), and lower fasting insulin (−29.0%) in PWS patients. Conclusions: Moreover, PWS subjects exhibited higher total cholesterol (+9.6%) and HDL-cholesterol (+19.8%), suggesting a more favourable lipid profile and no extra risk beyond severe obesity.
Epigenetic Age in Prader–Willi Syndrome and Essential Obesity: A Comparison with Chronological and Vascular Ages Antonello E. Rigamonti, Valentina Bollati, Benedetta Albetti, Diana Caroli, Adele Bondesan, Graziano Grugni, Silvano G. Cella, Alessandro Sartorio Journal of Clinical Medicine, 2025 Background: Prader–Willi syndrome (PWS) is a rare genetic disorder mapping to the imprinted 15q11-13 locus, specifically at the paternally expressed snord116 region, which has been implicated in controlling epigenetic mechanisms. Some aspects of the PWS-related clinical phenotype, such as the high mortality rate in adulthood, might be attributed to accelerated epigenetic ageing. Objectives: The aim of the present case–control study was to evaluate epigenetic age, age acceleration, vascular age (VA), and vascular ageing in adults with PWS (n = 24; F/M = 11/13; age = 36.8 [26.6; 45.3] years; body mass index, BMI = 36.8 [33.9; 44.8] kg/m2), compared with a sex- and age-matched group of subjects with essential obesity (EOB) (n = 36; F/M = 19/17; age = 43.4 [30.6; 49.5] years; BMI = 44.8 [41.2; 51.7] kg/m2). Results: In subjects with PWS, there was a younger epigenetic age and a lower age acceleration than in subjects with EOB. No differences were found between VA and vascular ageing in the two groups. Epigenetic age was associated with chronological age and VA within each group. For each group, no relevant associations of epigenetic age or age acceleration with demographic, biochemical, and clinical parameters were found. When considering individuals with PWS, there were no associations of epigenetic age with growth hormone (GH) deficiency, duration of hormone replacement therapy, and plasma levels of insulin-like growth factor 1 (IGF-1). Conclusions: The hypothesis of accelerated epigenetic ageing in PWS should be rejected. Additionally, considering the existence of a SNORD116-dependent epigenetic dysregulation in PWS, the results of the present study might be misleading, since an epigenetics-based approach was used to measure ageing.
Growth hormone treatment in adults with Prader-Willi syndrome: an update Graziano Grugni, Alessandro Sartorio Expert Review of Endocrinology and Metabolism, 2025 INTRODUCTION: Prader-Willi syndrome (PWS) is a rare disorder caused by the lack of expression of paternal genes on chromosome 15q11.2-q13. The clinical picture of PWS is characterized by neonatal hypotonia, hyperphagia, obesity, altered body composition, cognitive impairment, behavioral disturbances, short stature, and multiple endocrinopathies, including growth hormone (GH)/IGF-I axis dysfunction. AREAS COVERED: This narrative review addresses the current state-of-the-art of recombinant human GH therapy (rhGHT) in adults with PWS, focusing on its effects on body composition, muscle strength and exercise capacity, cardiovascular and respiratory function, endocrine and metabolic parameters, bone health, and psychological aspects. EXPERT OPINION: Available data demonstrated the positive effects of rhGHT on the body composition of GH-treated subjects. This observation is significant, as improving body composition has been shown to increase muscle strength and exercise tolerance. Overall, rhGHT appears to improve both cardiorespiratory function and psychological outcomes. However, most of the studies are uncontrolled and short-term. Therefore, longitudinal trials evaluating the long-term effects of rhGHT are recommended to confirm these findings. Since the beneficial effects of rhGHT appear to be independent of the presence of GH deficiency, we believe that its approval should be considered in adults with genetically confirmed PWS without testing for GH secretion.
Endocrine features of Prader-Willi syndrome: a narrative review focusing on genotype-phenotype correlation Simona F. Madeo, Luca Zagaroli, Sara Vandelli, Valeria Calcaterra, Antonino Crinò, Luisa De Sanctis, Maria Felicia Faienza, Danilo Fintini, Laura Guazzarotti, Maria Rosaria Licenziati, Enza Mozzillo, Roberta Pajno, Emanuela Scarano, Maria E. Street, Malgorzata Wasniewska, Sarah Bocchini, Carmen Bucolo, Raffaele Buganza, Mariangela Chiarito, Domenico Corica, Francesca Di Candia, Roberta Francavilla, Nadia Fratangeli, Nicola Improda, Letteria A. Morabito, Chiara Mozzato, Virginia Rossi, Concetta Schiavariello, Giovanni Farello, Lorenzo Iughetti, Vincenzo Salpietro, Alessandro Salvatoni, Mara Giordano, Graziano Grugni, Maurizio Delvecchio Frontiers in Endocrinology, 2024
Malignancies in Prader-Willi Syndrome: Results From a Large International Cohort and Literature Review Karlijn Pellikaan, Naomi Q C Nguyen, Anna G W Rosenberg, Muriel Coupaye, Anthony P Goldstone, Charlotte Høybye, Tania Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixàs, Christine Poitou, Raquel Corripio, Rosa M Nieuwenhuize, Aart J van der Lely, Laura C G de Graaff Journal of Clinical Endocrinology and Metabolism, 2023
The Italian registry for patients with Prader–Willi syndrome Marco Salvatore, Paola Torreri, Graziano Grugni, Adele Rocchetti, Mohamad Maghnie, Giuseppa Patti, Antonino Crinò, Maurizio Elia, Donatella Greco, Corrado Romano, Adriana Franzese, Enza Mozzillo, Annamaria Colao, Gabriella Pugliese, Uberto Pagotto, Valentina Lo Preiato, Emanuela Scarano, Concetta Schiavariello, Gianluca Tornese, Danilo Fintini, Sarah Bocchini, Sara Osimani, Luisa De Sanctis, Michele Sacco, Irene Rutigliano, Maurizio Delvecchio, Maria Felicia Faienza, Malgorzata Wasniewska, Domenico Corica, Stefano Stagi, Laura Guazzarotti, Pietro Maffei, Francesca Dassie, Domenica Taruscio Orphanet Journal of Rare Diseases, 2023
The treatment of obesity in children and adolescents: consensus position statement of the Italian society of pediatric endocrinology and diabetology, Italian Society of Pediatrics and Italian Society of Pediatric Surgery Claudio Maffeis, Francesca Olivieri, Giuliana Valerio, Elvira Verduci, Maria Rosaria Licenziati, Valeria Calcaterra, Gloria Pelizzo, Mariacarolina Salerno, Annamaria Staiano, Sergio Bernasconi, Raffaele Buganza, Antonino Crinò, Nicola Corciulo, Domenico Corica, Francesca Destro, Procolo Di Bonito, Mario Di Pietro, Anna Di Sessa, Luisa deSanctis, Maria Felicia Faienza, Grazia Filannino, Danilo Fintini, Elena Fornari, Roberto Franceschi, Francesca Franco, Adriana Franzese, Lia Franca Giusti, Graziano Grugni, Dario Iafusco, Lorenzo Iughetti, Riccardo Lera, Raffaele Limauro, Alice Maguolo, Valentina Mancioppi, Melania Manco, Emanuele Miraglia Del Giudice, Anita Morandi, Beatrice Moro, Enza Mozzillo, Ivana Rabbone, Paola Peverelli, Barbara Predieri, Salvo Purromuto, Stefano Stagi, Maria Elisabeth Street, Rita Tanas, Gianluca Tornese, Giuseppina Rosaria Umano, Malgorzata Wasniewska Italian Journal of Pediatrics, 2023
Kidney disease in adults with Prader-Willi syndrome: international cohort study and systematic literature review Denise H. van Abswoude, Karlijn Pellikaan, Naomi Nguyen, Anna G. W. Rosenberg, Kirsten Davidse, Franciska M. E. Hoekstra, Ilse M. Rood, Christine Poitou, Graziano Grugni, Charlotte Høybye, Tania P. Markovic, Assumpta Caixàs, Antonino Crinò, Sjoerd A. A. van den Berg, Aart J. van der Lely, Laura C. G. de Graaff Frontiers in Endocrinology, 2023
Bone Health in Adults With Prader-Willi Syndrome: Clinical Recommendations Based on a Multicenter Cohort Study Denise H van Abswoude, Karlijn Pellikaan, Anna G W Rosenberg, Kirsten Davidse, Muriel Coupaye, Charlotte Høybye, Tania P Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixàs, Christine Poitou, Helena Mosbah, Tessa Weir, Leo A van Vlimmeren, Joost P H J Rutges, Luuk W L De Klerk, M Carola Zillikens, Aart J van der Lely, Laura C G de Graaff Journal of Clinical Endocrinology and Metabolism, 2023
Hyperprolactinemia in adults with prader-willi syndrome Anna Sjöström, Karlijn Pellikaan, Henrik Sjöström, Anthony P. Goldstone, Graziano Grugni, Antonino Crinò, Laura C. G. De Graaff, Charlotte Höybye Journal of Clinical Medicine, 2021
Central adrenal insufficiency is rare in adults with prader–willi syndrome Anna G W Rosenberg, Karlijn Pellikaan, Christine Poitou, Anthony P Goldstone, Charlotte Høybye, Tania Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixàs, Muriel Coupaye, Sjoerd A A Van Den Berg, Aart Jan Van Der Lely, Laura C G De Graaff Journal of Clinical Endocrinology and Metabolism, 2020
Changes in symmetry during gait in adults with Prader-Willi syndrome Veronica Cimolin, Massimiliano Pau, Nicola Cau, Bruno Leban, Micaela Porta, Paolo Capodaglio, Alessandro Sartorio, Graziano Grugni, Manuela Galli Computer Methods in Biomechanics and Biomedical Engineering, 2020
Anthropometric characteristics of newborns with Prader–Willi syndrome Alessandro Salvatoni, Alex Moretti, Graziano Grugni, Massimo Agosti, Sara Azzolini, Valentina Bonaita, Paola Cianci, Domenico Corica, Antonino Crinò, Maurizio Delvecchio, Silvio Ferraris, Nella A. Greggio, Lorenzo Iughetti, Maria R. Licenziati, Simona F. Madeo, Luana Nosetti, Roberta Pajno, Irene Rutigliano, Michele Sacco, Silvia Salvatore, Emanuela Scarano, Giuliana Trifirò, Malgorzata Wasniewska American Journal of Medical Genetics Part A, 2019
Uniparental disomy and pretreatment IGF-1 may predict elevated IGF-1 levels in Prader-Willi patients on GH treatment Viviana Valeria Palmieri, Antonella Lonero, Sarah Bocchini, Gilda Cassano, Alessio Convertino, Domenico Corica, Antonio Crinò, Valentina Fattorusso, Silvio Ferraris, Danilo Fintini, Adriana Franzese, Graziano Grugni, Lorenzo Iughetti, Rosanna Lia, Francesca Macchi, Simona Filomena Madeo, Patrizia Matarazzo, Luana Nosetti, Sara Osimani, Roberta Pajno, Giuseppa Patti, Maria Chiara Pellegrin, Annamaria Perri, Letizia Ragusa, Irene Rutigliano, Michele Sacco, Alessandro Salvatoni, Emanuela Scarano, Stefano Stagi, Gianluca Tornese, Giuliana Trifirò, Malgorzata Wasniewska, Rita Fischetto, Paola Giordano, Maria Rosaria Licenziati, Maurizio Delvecchio Growth Hormone and IGF Research, 2019
Thyroid function in patients with Prader-Willi syndrome: An Italian multicenter study of 339 patients Lorenzo Iughetti, Giulia Vivi, Antonio Balsamo, Andrea Corrias, Antonino Crinò, Maurizio Delvecchio, Luigi Gargantini, Nella Augusta Greggio, Graziano Grugni, Uros Hladnik, Alba Pilotta, Letizia Ragusa, Alessandro Salvatoni, Malgorzata Wasniewska, Giovanna Weber, Barbara Predieri Journal of Pediatric Endocrinology and Metabolism, 2019
Diagnosis, treatment and prevention of pediatric obesity: Consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics Giuliana Valerio, Claudio Maffeis, Giuseppe Saggese, Maria Amalia Ambruzzi, Antonio Balsamo, Simonetta Bellone, Marcello Bergamini, Sergio Bernasconi, Gianni Bona, Valeria Calcaterra, Teresa Canali, Margherita Caroli, Francesco Chiarelli, Nicola Corciulo, Antonino Crinò, Procolo Di Bonito, Violetta Di Pietrantonio, Mario Di Pietro, Anna Di Sessa, Antonella Diamanti, Mattia Doria, Danilo Fintini, Roberto Franceschi, Adriana Franzese, Marco Giussani, Graziano Grugni, Dario Iafusco, Lorenzo Iughetti, Adima Lamborghini, Maria Rosaria Licenziati, Raffaele Limauro, Giulio Maltoni, Melania Manco, Leonardo Marchesini Reggiani, Loredana Marcovecchio, Alberto Marsciani, Emanuele Miraglia del Giudice, Anita Morandi, Giuseppe Morino, Beatrice Moro, Valerio Nobili, Laura Perrone, Marina Picca, Angelo Pietrobelli, Francesco Privitera, Salvatore Purromuto, Letizia Ragusa, Roberta Ricotti, Francesca Santamaria, Chiara Sartori, Stefano Stilli, Maria Elisabeth Street, Rita Tanas, Giuliana Trifiró, Giuseppina Rosaria Umano, Andrea Vania, Elvira Verduci, Eugenio Zito Italian Journal of Pediatrics, 2018
Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH) Marco Bonomi, Valeria Vezzoli, Csilla Krausz, Fabiana Guizzardi, Silvia Vezzani, Manuela Simoni, Ivan Bassi, Paolo Duminuco, Natascia Di Iorgi, Claudia Giavoli, Alessandro Pizzocaro, Gianni Russo, Mirella Moro, Letizia Fatti, Alberto Ferlin, Laura Mazzanti, Maria Chiara Zatelli, Salvo Cannavò, Andrea M Isidori, Angela Ida Pincelli, Flavia Prodam, Antonio Mancini, Paolo Limone, Maria Laura Tanda, Rossella Gaudino, Mariacarolina Salerno, Pregnolato Francesca, Mohamad Maghnie, Mario Maggi, Luca Persani, _ _, _ _, G Aimaretti, M Altobelli, M R Ambrosio, M Andrioli, G Angeletti, F Arecco, G Arnaldi, M Arosio, A Balsamo, M Baldassarri, L Bartalena, N Bazzoni, L Beccaria, P Beck-Peccoz, G Bellastella, M Bellizzi, F Benedicenti, S Bernasconi, C Bizzarri, G Bona, S Bonadonna, G Borretta, M Boschetti, A Brunani, V Brunelli, F Buzi, C Cacciatore, B Cangiano, M Cappa, R Casalone, A Cassio, P Cavarzere, V Cherubini, T Ciampani, D Cicognani, A Cignarelli, M Cisternino, P Colombo, S Corbetta, N Corciulo, G Corona, R Cozzi, C Crivellaro, I Dalle Mule, L Danesi, A V D’Elia, E degli Uberti, S De Leo, E Della Valle, M De Marchi, N Di Iorgi, A Di Mambro, A Fabbri, C Foresta, G Forti, A R Franceschi, A Garolla, M Ghezzi, C Giacomozzi, M Giusti, E Grosso, G Guabello, M P Guarneri, G Grugni, A M Isidori, F Lanfranco, A Lania, R Lanzi, L Larizza, A Lenzi, S Loche, P Loli, V Lombardi, M C Maggio, G Mandrile, C Manieri, G Mantovani, S Marelli, M Marzullo, M A Mencarelli, N Migone, G Motta, G Neri, G Padova, G Parenti, B Pasquino, A Pia, E Piantanida, E Pignatti, A Pilotta, B Pivetta, M Pollazzon, A Pontecorvi, P Porcelli, G B Pozzan, G Pozzobon, G Radetti, P Razzore, L Rocchetti, R Roncoroni, G Rossi, E Sala, A Salvatoni, F Salvini, A Secco, M Segni, R Selice, P Sgaramella, F Sileo, A A Sinisi, F Sirchia, A Spada, A Tresoldi, R Vigneri, G Weber, S Zucchini European Journal of Endocrinology, 2018
Growth hormone therapy and respiratory disorders: Long-term follow-up in PWS children Jenny Berini, Valeria Spica Russotto, Paolo Castelnuovo, Stefania Di Candia, Luigi Gargantini, Graziano Grugni, Lorenzo Iughetti, Luigi Nespoli, Luana Nosetti, Giovanni Padoan, Alba Pilotta, Giuliana Trifirò, Giuseppe Chiumello, Alessandro Salvatoni, on behalf of the Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology, Diabetology (ISPED) Journal of Clinical Endocrinology and Metabolism, 2013
Central adrenal insufficiency in young adults with Prader-Willi Syndrome Graziano Grugni, Luciano Beccaria, Andrea Corrias, Antonino Crinò, Marco Cappa, Clotilde De Medici, Stefania Di Candia, Luigi Gargantini, Letizia Ragusa, Alessandro Salvatoni, Alessandro Sartorio, Sabrina Spera, Simeone Andrulli, Giuseppe Chiumello, Alessandro Mussa, the Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology, Diabetology (ISPED) Clinical Endocrinology, 2013
Metabolic syndrome in adult patients with Prader-Willi syndrome G. Grugni, A. Crinò, G. Bedogni, M. Cappa, A. Sartorio, A. Corrias, S. Di Candia, L. Gargantini, L. Iughetti, C. Pagano, L. Ragusa, A. Salvatoni, S. Spera, R. Vettor, G. Chiumello, P. Brambilla Nutrition Metabolism and Cardiovascular Diseases, 2013
Management of children and adolescents with severe obesity Minerva Pediatrica, 2012
Assessment of central adrenal insufficiency in children and adolescents with Prader-Willi syndrome Andrea Corrias, Graziano Grugni, Antonino Crinò, Stefania Di Candia, Patrizia Chiabotto, Anna Cogliardi, Giuseppe Chiumello, Clotilde De Medici, Sabrina Spera, Luigi Gargantini, Lorenzo Iughetti, Antonella Luce, Benedetta Mariani, Letizia Ragusa, Alessandro Salvatoni, Simeone Andrulli, Alessandro Mussa, Luciano Beccaria, on behalf of the Study Group for Genetic Obesity of the Italian Society of Pediatric Endocrinology, Diabetology (SIEDP/ISPED) Clinical Endocrinology, 2012
POI: A score to modulate GH treatment in children with prader-willi syndrome A. Salvatoni, J. Berini, G. Chiumello, A. Crinò, S. Di Candia, L. Gargantini, G. Grugni, L. Iughetti, A. Luce, G. Musolino, P. Sogno Valin, V. Spica Russotto, G. Trifirò, on behalf of the Genetic Obesity Study Group of the Italian Society of Paediatric Endocrinology, Diabetology (ISPED) Hormone Research in Paediatrics, 2012
The use of local reference growth charts for clinical use or a universal standard: A balanced appraisal S. Milani, J. M. H. Buckler, C. J. H. Kelnar, L. Benso, G. Gilli, I. Nicoletti, G. Faglia, G. Radetti, G. Bona, Y. Schonbeck, S. Van Buuren, M. Hermanussen, G. Grugni, N. Marazzi, P. B. Júlíusson, M. Roelants, K. Hoppenbrouwers, R. Hauspie, R. Bjerknes, H. Lejarraga, A. Sartorio Journal of Endocrinological Investigation, 2012
The metabolic syndrome among obese adolescents A. Sartorio, F. Agosti, A. De Col, E. Compri, G. Grugni, W. Siegfried, F. Adorni, C. L. Lafortuna Journal of Endocrinological Investigation, 2011
Gait patterns in Prader-Willi and Down syndrome patients Veronica Cimolin, Manuela Galli, Graziano Grugni, Luca Vismara, Giorgio Albertini, Chiara Rigoldi, Paolo Capodaglio Journal of Neuroengineering and Rehabilitation, 2010
A survey on prader-willi syndrome in the italian population: Prevalence of historical and clinical signs A. Crinò, G. Di Giorgio, C. Livieri, G. Grugni, L. Beccaria, L. Bosio, A. Corrias, G. Chiumello, G. Trifirò,, A. Salvatoni, G. Tonini, L. Gargantini, T. de Toni, G. Valerio, L. Ragusa, A. Franzese, M.M. Rinaldi, S. Spera, G. Castelli Gattinara, S. Villani, L. Iughetti, Genetic Obesity Study Group of the (ISPED) Journal of Pediatric Endocrinology and Metabolism, 2009
The Italian national survey for Prader-Willi syndrome: An epidemiologic study Graziano Grugni, Antonino Crinò, Laura Bosio, Andrea Corrias, Marina Cuttini, Teresa De Toni, Eliana Di Battista, Adriana Franzese, Luigi Gargantini, Nella Greggio, Lorenzo Iughetti, Chiara Livieri, Arturo Naselli, Claudio Pagano, Giovanni Pozzan, Letizia Ragusa, Alessandro Salvatoni, Giuliana Trifirò, Luciano Beccaria, Maria Bellizzi, Jaele Bellone, Amelia Brunani, Marco Cappa, Gabriella Caselli, Valeria Cerioni, Maurizio Delvecchio, Daniela Giardino, Francesco Iannì, Luigi Memo, Alba Pilotta, Cristoforo Pomara, Giorgio Radetti, Michele Sacco, Annarosa Sanzari, Alessandro Sartorio, Giorgio Tonini, Roberto Vettor, Federico Zaglia, Giuseppe Chiumello, on behalf of the Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology, Diabetology (ISPED) American Journal of Medical Genetics Part A, 2008
Circadian rhythm of melatonin (aMT) in liver cirrhosis Minerva Medica, 1998
Growth hormone response to hexarelin, growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen in prepubertal and early pubertal short children. Minerva Endocrinologica, 1998
Leptin and neuropeptide Y serum levls in young obese during weight loss Minerva Endocrinologica, 1998
Knemometry in the assessment of short term effects of growth hormone therapy in children with several growth disorders Minerva Pediatrica, 1997
Usefulness of knemometry in the assessment of oxandrolone effects and role of infections in short-term growth within constitutional growth delay Acta Medica Auxologica, 1997
Dexfenfluramine in the treatment of juvenile obesity Minerva Pediatrica, 1997
Effects of protracted rhGH administration on body composition and intermediate metabolism in juvenile obesity Acta Medica Auxologica, 1996
Epidemiology of childhood obesity: Prevalence in north-west Italy Minerva Pediatrica, 1996
Effect of sex on the increase of GH induced by galanin, alone or in combination with GHRH with or without pyridostigmine in pubescent subjects Minerva Endocrinologica, 1996
Dexfenfluramine in the treatment of prepubertal subjects with essential obesity Acta Medica Auxologica, 1995
Effects of treatment with rhGH on erythropoiesis in adults with hypopituitarism Acta Medica Auxologica, 1995
On the spontaneous and stimulated GH secretion in subjects with constitutional growth delay during short-term treatment with oxandrolone Acta Medica Auxologica, 1994
Prolactin secretion during hepatic cirrhosis Minerva Medica, 1994
Melatonin levels in psychogenic impotence G. Grugni, C. Carani, G. Maestroni, G. Guzzaloni, A. Ardizzi, P. Lissoni, A. Granata, F. Morabito Hormone and Metabolic Research, 1994
Study of melatonin secretory pattern in Klinefelter's syndrome Archivio Italiano Di Urologia Nefrologia Andrologia, 1993
Circulating molecular forms in patients with Prader-Willi syndrome Dysmorphology and Clinical Genetics, 1992
The TRH test in Turner syndrome Minerva Endocrinologica, 1992
Relationship between lipidemia indices and body mass index in obesity Minerva Medica, 1991
Study of relations between insulinemia and high blood pressure in adult obese subjects Minerva Medica, 1991
On the interest of dosage of glycated plasma proteins in the diagnostic of glucidic intolerance in obesity Minerva Medica, 1990
Persistent pituitary-adrenal responsiveness to repeated CRH injections in normal subjects and in patients with Cushing's disease Neuroendocrinology Letters, 1990
Relation between the age of the parents and achondroplasia Minerva Pediatrica, 1987
Modifications in certain indicators of thyroid function in obese adults under diet therapy Minerva Medica, 1987
Giedion syndrome with a 46,XY karyotype in a female subject Pathologica, 1986
A clinical study of interactions between opioid, serotoninergic and histaminergic systems in regulating prolactin secretion Acta Medica Auxologica, 1986
