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Scopus Publications
- Bacterial sepsis in Brazilian children: A Trend Analysis from 1992 to 2006
Cristina Malzoni Ferreira Mangia, Niranjan Kissoon, Otavio Augusto Branchini, Maria Cristina Andrade, Benjamin Israel Kopelman, et al.
Plos One, 2011
BACKGROUND The objective of this study was to determine the epidemiology of hospitalized pediatric sepsis in Brazil (1992-2006) and to compare mortality caused by sepsis to that caused by other major childhood diseases. METHODS AND FINDINGS We performed a retrospective descriptive study of hospital admissions using a government database of all hospital affiliated with the Brazilian health system. We studied all hospitalizations in children from 28 days through 19 years with diagnosis of bacterial sepsis defined by the criteria of the International Classification of Diseases (ICD), (Appendix S1). Based on the data studied from 1992 through 2006, the pediatric hospital mortality rate was 1.23% and there were 556,073 pediatric admissions with bacterial sepsis with a mean mortality rate of 19.9%. There was a case reduction of 67% over 1992-2006 (p<0.001); however, the mortality rate remained unchanged (from 1992-1996, 20.5%; and from 2002-2006, 19.7%). Sepsis-hospital mortality rate was substantially higher than pneumonia (0.5%), HIV (3.3%), diarrhea (0.3%), undernutrition (2.3%), malaria (0.2%) and measles (0.7%). The human development index (HDI) and mortality rates (MR) by region were: North region 0.76 and 21.7%; Northeast region 0.72 and 27.1%; Central-West 0.81 and 23.5%; South region 0.83 and 12.2% and Southeast region 0.82 and 14.8%, respectively. CONCLUSIONS We concluded that sepsis remains an important health problem in children in Brazil. The institution of universal primary care programs has been associated with substantially reduced sepsis incidence and therefore deaths; however, hospital mortality rates in children with sepsis remain unchanged. Implementation of additional health initiatives to reduce sepsis mortality in hospitalized patients could have great impact on childhood mortality rates in Brazil. - Sepsis and septic shock: A global overview
Cristina Mangia, Joseph Carcillo, Niranjan Kissoon
Journal of Pediatric Infectious Diseases, 2009
Severe sepsis and septic shock are life-threatening diseases in both developed and developing countries and is an important risk factor for morbidity and mortality in all age groups. In developing countries, there is a direct relationship between the incidence of infections and mortality under five years of age. Child mortality in these scenarios is complex and involves issues such as lack of preventative care, malnutrition, poverty, and lack of resources, that together contribute to the increased incidence and poor outcomes in sepsis. The concept of integrated management of childhood illness that involves the community, family and health systems is an important way that has been proposed for reduce children mortality and morbidity in developing nations and should be applied in sepsis initiatives. Sepsis and septic shock are observed time-sensitive, early diagnosis and prompt treatment have been related to good outcome. Actions such as prevention sound public health policies, educational programs for health care providers, family and community may help to reduce the global burden of this disease in children. - Anomalous left coronary artery from pulmonary artery: Autogenous arterial tube for aortic implantation
Journal of Cardiovascular Surgery, 2004 - Cerebral sinovenous thrombosis in a nephrotic child
Marcelo Masruha Rodrigues, Lilian Rocha Zardini, Maria Cristina de Andrade, Cristina Malzoni Ferreira Mangia, João Tomas de Abreu Carvalhaes, et al.
Arquivos De Neuro Psiquiatria, 2003
Nephrotic syndrome in infancy and childhood is known to be associated with a hypercoagulable state and thromboembolic complications, but cerebral sinovenous thrombosis (CST) is a very rare and serious one, with only a few isolated reports in the literature. A case is presented of a 9-year-old boy with nephrotic syndrome that acutely developed signs and symptoms of intracranial hypertension syndrome. CST was diagnosed on cranial CT and MRI and he gradually recovered after treatment with anticoagulants. The diagnosis of CST should be considered in any patient with nephrotic syndrome who develops neurologic symptoms. The discussion of this case, coupled with a review of the literature, emphasizes that early diagnosis is essential for institution of anticoagulation therapy and a successful outcome. This report also illustrates the difficulties that may be encountered in managing such a patient. - Conventional and conventional plus modified ultrafiltration during cardiac surgery in high-risk congenital heart disease
Journal of Cardiovascular Surgery, 2001 - Management of acute seizure episodes and status epilepticus in children
Erasmo B. Casella, Cristina M. F. Mângia
Jornal De Pediatria, 1999
OBJECTIVE: The authors make an up-to-date review about diagnosis and treatment of the acute seizures and status epilepticus.METHODS: Bibliographic review of Medline database including articles published in the last ten years.RESULTS: Acute seizures and status epilepticus affect children of all the age groups. Acute seizures can either represent the first manifestation of an epileptic condition or be an acute symptomatic event. Status epilepticus represents a serious cerebral insult determined by various causes. The emergency, neurology and pediatric intensive care units should elaborate clinical policy for the establishment of precise diagnostic criteria and therapeutic approach. A good clinical approach should include immediate life support, monitoring and rational drug administration to end up the seizure and reduce morbidity and mortality risks.CONCLUSION: The better understanding of the pathophysiology as well as the elaboration of a rational clinical policy improved the outcome in these medical emergencies. - Withdrawal syndrome associated with cessation of fentanyl and midazolam in pediatrics
J.N. Bicudo, N. de Souza, C.M.F. Mângia, W.B. de Carvalho
Revista Da Associacao Medica Brasileira 1992, 1999
PURPOSE: To determine the incidence of abstinence syndrome in children interned in the Pediatric Intensive Care Unit (PICU) in fentanyl use and midazolam METHODS: Evaluation of 36 children interned in PICU of the Hospital Sao Paulo - Federal University of Sao Paulo, in the period from March to September 1997, with age varying from 5 days to 22 months (22 masc: 14 fem) who used fentanyl use and midazolam for more than 24 hours. Used the Escore Neonatal of Abstinence adapted by Finnegan determines the occurrence of abstinence syndrome in was used to children 2 years old or less. Sustain larger or equal for 8 is considered as abstinence syndrome. Correlated the abstinence syndrome with the accumulated total dose, infusion velocity, daily dose and time of use of the fentanyl and midazolam. RESULTS: Certain abstinence syndrome in 18 (50%) of the 36 children. Applied Mann Whitney's statistical test to compare the groups with and without abstinence syndrome. Dose accumulated of fentanyl total (5732.7 ± 5114.91 vs 624.2 ± 591.2 mcg, p < 0.005), dose daily of fentanyl (98.54 ± 6.12 vs 36.23 ± 23.42 mcg/Kg/dia, p < 0.005), velocity of infusion of the fentayl (4.09 ± 2.75 vs 1.5 ± 0.95 mcg/Kg/hora, p < 0.005), time of use of the fentanyl (10.2 ± 5.1 vs 3.16 ± 1.09 days, p < 0.005), dose accumulated of midazolam total (118.8 ± 86.97 vs 20.03 ± 14.79 mg, p < 0.005), dose daily of midazolam (2.32 ± 0.86 vs 1.21 ± 0.68 mg/Kg/dia, p < 0.005), velocity of midazolam infusion (0.13 ± 0.16 vs 0.05 ± 0.02 mg/Kg/hora, p < 0.005) and time of use of the midazolam (9.20 ± 4.67 vs 2.55 ± 1.54 days, p < 0.005) they were considered significant. CONCLUSION: The abstinence syndrome presents an elevated incidence in children interned in PICU owing to the interruption of the fentanyl infusion and midazolam and in these patients it was related with the dose and the time of use. - Use of total body impedance index in cardiac surgery with cardiopulmonary bypass in children
Werther B. Carvalho, Cristina M. F. Mangia, Nilton F. Oliveira, Joao A. Mattar, Miguel A. Maluf, et al.
Critical Care Medicine, 1999 - Effects on the pulmonary function after single dose of exogenous pulmonary surfactant in children with acute respiratory distress syndrome
W.B. de Carvalho, C.M.F. Mângia
Revista Da Associacao Medica Brasileira 1992, 1997
The Acute Respiratory Distress Syndrome (ARDS) is a pulmonary lesion of multifactorial cause in which the surfactant system is altered owing to inactivation and impairment of composition and metabolism. The use of exogenous pulmonary surfactant is a therapeutic option with the objective to maintain alveolar stability thus improving the pulmonary compliance (increasing the residual functional capacity), oxygenation and ventilatory mechanics. A study carried out on two pediatric patients with ARDS submitted to mechanic pulmonary ventilation, applying a single dose of exogenous pulmonary surfactant is described. The patients were evaluated using arterial and venous gasometry before and after the use of surfactant, observing increment in oxygenation, reduction of shunt fraction, improvement in ventilation immediately after exogenous pulmonary surfactant instillation and return to the previous situation after 240 minutes in case 1 and 120 minutes in case 2. More prospective clinical and randomized studies are needed to effectively evaluate this therapeutic modality.
RECENT SCHOLAR PUBLICATIONS
- ALTERAÇOES POSTURAIS EM CRIANÇAS E ADOLESCENTES APOS TRANSPLANTE RENAL
MC de Andrade, ACR GAMA, C MANGIA, AP BRECHERET, ...
Medical Proceedings 6 (1), 57-58 , 2025
2025 - PP402 Topic: AS13–Hematology/Oncology/Stem Cell Transplant/Immunology: PERIPHERAL BLOOD SMEAR REVIEW BY HEMATOLOGISTS IN PEDIATRIC EMERGENCIES AND INTENSIVE CARE
C Assis, C Lopes, C Mangia, C Goulart, AT Fernandes, A Carneluti, ...
Pediatric Critical Care Medicine 25 (11S), e123-e124 , 2024
2024 - OP050 Topic: AS14–Infections: Sepsis and Septic Shock/Antimicrobial Stewardship/Tropical and Parasite Infections/Other: MTHFR GENE POLYMORPHISM INDUCE ENDOTHELIAL-MACROPHAGE …
C Mangia, C Goulart, C Santin, C Mozzatto, M Acras, C Assis, ...
Pediatric Critical Care Medicine 25 (11S), e19-e19 , 2024
2024 - PP037 Topic: AS04–Emerging Sciences, Methodologies, Big Data and Technology: OFFLINE DATABASE MODELING PLATFORM BY BAYSEAN APPROACH: DEVELOPMENT DATA INCONSISTENCY AND MISSING …
C Mangia, C Goulart, AT Fernandes, A Carneluti, L Correa, F Vidal, ...
Pediatric Critical Care Medicine 25 (11S), e32 , 2024
2024 - PP391 Topic: AS14–Infections: Sepsis and Septic Shock/Antimicrobial Stewardship/Tropical and Parasite Infections/Other: CLINICAL RECOGNITION OF SEPTIC SHOCK IN CHILDREN AND …
A Carneluti, C Mangia, AT Fernandes, A Carneluti, C Silva, F Meneses, ...
Pediatric Critical Care Medicine 25 (11S), e120 , 2024
2024 - PP038 Topic: AS04–Emerging Sciences, Methodologies, Big Data and Technology: HEALTH SCIENCE UPDATE–ADVANCED STUDY GROUP (HEAL) WEBPAGE JAC SEPSIS INITIATIVE
C Mangia, C Goulart, AT Fernandes, A Carneluti, L Correa, F Vidal, ...
Pediatric Critical Care Medicine 25 (11S), e32-e33 , 2024
2024 - PP006 Topic: AS09–Global Health/Resource Limited Setting/Health Inequalities/Impact of Global Warming/Other: UNDERSTANDING COVID-19 WIDESPREAD IN THE LEGAL AMAZON BY SOCIAL …
A Carneluti, M Freitas, R Dagnino, G Canalez, A Carneluti, E Barros, ...
Pediatric Critical Care Medicine 25 (11S), e24-e25 , 2024
2024 - PP421 Topic: AS09–Global Health/Resource Limited Setting/Health Inequalities/Impact of Global Warming/Other: SEPSIS, PNEUMONIA, AND DIARRHEAL INCIDENCE AND OUTCOMES IN …
C Mangia, C Goulart, A Carneluti, F Vidal, L Correa, R Rossi, KL Maciel, ...
Pediatric Critical Care Medicine 25 (11S), e127-e128 , 2024
2024 - PP042 Topic: AS04–Emerging Sciences, Methodologies, Big Data and Technology: THE SOCIAL MEDIA SOLUTION: BRIDGING THE GAP IN HEALTH SCIENCE EDUCATION WITH WHATSAPP (COVID-19 …
C Mangia, A Carneluti, C Goulart, L Correa, C Lopes, S Moutinho, C Silva, ...
Pediatric Critical Care Medicine 25 (11S), e33 , 2024
2024 - PP390 Topic: AS14–Infections: Sepsis and Septic Shock/Antimicrobial Stewardship/Tropical and Parasite Infections/Other: PEDIATRIC OUTCOME AFTER CLINICAL PRACTICE PARAMETERS FOR …
A Carneluti, C Mangia, A Carneluti, M Toledo, F Meneses, R Rossi, ...
Pediatric Critical Care Medicine 25 (11S), e119-e120 , 2024
2024 - PP458 Topic: AS16–Medical, Nursing and AHP Workforce & Education: Staff Education and Development/Equity, Diversity, Inclusion/Other: CUTTING-EDGE HEALTH SCIENCE UPDATE (HEAL …
C Mangia, AT Fernandes, R Rossi, M Toledo, KL Maciel, F Meneses, ...
Pediatric Critical Care Medicine 25 (11S), e137 , 2024
2024 - Clinical Recognition of Septic Shock in Children and Adolescents
C MANGIA, A Carneluti, F Meneses, AT Fernandes, A Carneluti, ...
Available at SSRN 4787689 , 2024
2024 - Understanding Covid-19 widespread in Brazil and the Legal Amazon by social, environmental and human mobility factors
MWD Freitas, RS Dagnino, CMF Mangia, GG Canalez, EF Barros, ...
Sociedade de riscos sanitários [recurso eletrônico]. Curitiba, Pr: CRV, 2023 … , 2023
2023 - Performance of Brazilian pediatric risk of severity Model for illness (BRPRISM) compared to pediatric index of mortality and pediatric risk of mortality 2
CMF Mangia, MD Toledo, R Rossi, EY Nakano, A Carneluti
Eur J Pedia Neon: EJPN-103 , 2023
2023
Citations: 1 - Repeatability and Reproducibility (RR) of Bioelectric Impedance Vectors in Brazilian Children with Normal Body Mass
CMF Mangia, A Carneluti, BI Kopelman, WB de Carvalho, MC Andrade
Eur J Pedia Neon: EJPN-102 , 2023
2023 - Reference Bioelectrical Impedance Values for Children of Normal Body Mass Index in Southeastern Brazil
CMF Mangia, A Carneluti, MC Andrade
Asian Journal of Pediatric Research 4 (3), 7-17 , 2020
2020 - CRITÉRIO pRIFLE EM CRIANÇAS CRITICAMENTE DOENTES
MC Andrade, C Mangia, NF Oliveira
Blucher Medical Proceedings 6 (1), 59-60 , 2020
2020 - Interactive methodologies to facilitate the integration of the Human Semiology Curricular Unit
MC Andrade, C Mangia, E Barragán, R Diniz, MWL Strufaldi, RHP Mennin
Revista Eletrônica de Educação 13 (2), 632-644 , 2019
2019
Citations: 2 - Metodologías interactivas para facilitar la integración de la Unidad Curricular de Semiología Humana
MC Andrade, C Mangia, E Barragán, R Diniz, MWL Strufaldi, RHP Mennin
Revista Eletrônica de Educação 13 (2), 632-644 , 2019
2019 - Epidemiological aspects of kidney failure in hospitalized children in Brazil
C Mangia, M Andrade
J Nephrol Ther 6 (245), 2161-70 , 2015
2015
Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
- Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012
RPMD Dellinger, MMMD Levy, AMBBS Rhodes, DMD Annane, ...
Critical Care Medicine 41 (2), 580 - 637 , 2013
2013
Citations: 23133 - Surviving sepsis campaign
RP Dellinger, MM Levy, A Rhodes, D Annane, H Gerlach, SM Opal, ...
Critical care medicine 41 (2), 580-637 , 2013
2013
Citations: 1599 - Bacterial sepsis in Brazilian children: a trend analysis from 1992 to 2006
CMF Mangia, N Kissoon, OA Branchini, MC Andrade, BI Kopelman, ...
PloS one 6 (6), e14817 , 2011
2011
Citations: 61 - Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Critical care medicine 41 (2), 580-637 , 2013
2013
Citations: 60 - Conventional and conventional plus modified ultrafiltration during cardiac surgery in high-risk congenital heart disease
MA Maluf, C Mangia, C Silva, WB Carvalho
Journal Of Cardiovascular Surgery 42 (4), 465 , 2001
2001
Citations: 35 - Sepsis and septic shock: a global overview
CMF Mangia, N Kissoon, JA Carcillo
Journal of Pediatric Infectious Diseases 4 (02), 071-076 , 2009
2009
Citations: 26 - Cerebral sinovenous thrombosis in a nephrotic child
MM Rodrigues, LR Zardini, MC Andrade, CMF Mangia, JTA Carvalhaes, ...
Arquivos de neuro-psiquiatria 61 (4), 1026-1029 , 2003
2003
Citations: 26 - Withdrawal syndrome associated with cessation of fentanyl and midazolam in pediatrics
JN Bicudo, N Souza, CMF Mângia, WB De Carvalho
Revista Da Associação Médica Brasileira 45, 15-18 , 1999
1999
Citations: 14 - Estudo comparativo da ultrafiltração convencional e associação de ultrafiltração convencional e modificada na correção de cardiopatias congênitas com alto risco cirúrgico
MA Maluf, C Mangia, J Bertuccez, C Silva, R Catani, W Carvalho, ...
Brazilian Journal of Cardiovascular Surgery 14 (3), 221-236 , 1999
1999
Citations: 12 - Síndrome de abstinência associada à interrupção da infusão de fentanil e midazolam em pediatria
JN Bicudo, N Souza, CMF Mângia, WB Carvalho
Revista da Associação Médica Brasileira 45 (1), 15-18 , 1999
1999
Citations: 12 - Hemolytic‐Uremic Syndrome in Uberlândia, MG, Brazil
V Bonetti, CMF Mangia, JMF Zuza, MO Barcelos, MMS Fonseca, SP Nery, ...
International Scholarly Research Notices 2011 (1), 651749 , 2011
2011
Citations: 9 - Abordagem da crise convulsiva aguda e estado de mal epiléptico em crianças
EB Casella, CMF Mângia
J Pediatr (Rio J) 75 (Supl 2), s197-s206 , 1999
1999
Citations: 9 - Management of acute seizure episodes and status epilepticus in children
EB Casella, CM Mangia
Jornal de Pediatria 75, S197-206 , 1999
1999
Citations: 7 - Efeitos na função pulmonar após utilização de surfactante pulmonar exógeno na síndrome do desconforto respiratório agudo na criança
WB Carvalho, CMF Mângia
Revista da Associação Médica Brasileira 43 (2), 145-150 , 1997
1997
Citations: 6 - Epidemiological aspects of kidney failure in hospitalized children in Brazil
C Mangia, M Andrade
J Nephrol Ther 6 (245), 2161-70 , 2015
2015
Citations: 4 - Ventilação Pulmonar Mecânica Convencional em Neonatologia
WB CARVALHO, CMF Mangia
____. Ventilação mecânica: básico. São Paulo: Atheneu, 147-1888 , 2000
2000
Citations: 4 - Anomalous left coronary artery from pulmonary artery: autogenous arterial tube for aortic implantation
MA Maluf, CM Mangia, MS Diogenes, A Carvalho, E Buffolo
Journal of Cardiovascular Surgery 45 (6), 577 , 2004
2004
Citations: 3 - Interactive methodologies to facilitate the integration of the Human Semiology Curricular Unit
MC Andrade, C Mangia, E Barragán, R Diniz, MWL Strufaldi, RHP Mennin
Revista Eletrônica de Educação 13 (2), 632-644 , 2019
2019
Citations: 2 - Influence of vasopressor agent in pediatric septic shock mortality
CMF Mangia, LPS Jose, FL Monteiro, AT Fernandes, P Biasi, F Menezes, ...
Critical Care 15 (Suppl 2), P16 , 2011
2011
Citations: 2 - Atualização no diagnóstico e tratamento sepse grave e choque séptico em pediatria
CMF Mângia, WB Carvalho
Atualização no diagnóstico e tratamento sepse grave e choque séptico em … , 2005
2005
Citations: 2